Structure–functional intimacies of transient receptor potential channels

• Published in: Quarterly reviews of biophysics Vol. 42; no. 3; pp. 201 - 246
• Main Authors: Latorre, Ramon, Zaelzer, Cristián, Brauchi, Sebastian
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.08.2009
• Subjects: Amino acids; Animals; Biophysics; Humans; Models, Biological; Mutagenesis; Permeability; Proteins; TRPC Cation Channels - chemistry; TRPC Cation Channels - genetics; TRPC Cation Channels - metabolism

Although a unifying characteristic common to all transient receptor potential (TRP) channel functions remains elusive, they could be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability....