Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG - Wang, Weiwei; MacKinnon, Roderick (Cell, 2017)
Keywords: action potentials; Amino Acid Sequence; arrhythmia; chemical structure; cryo-electron microscopy; cryo-EM; Cryoelectron Microscopy; drug-induced Long QT; drugs; ERG1 Potassium Channel - chemistry; ERG1 Potassium Channel - isolation & purification; ERG1 Potassium Channel - metabolism; ERG1 Potassium Channel - ultrastructure; hERG; hERG block; Humans; hydrophobicity; inactivation; K+ channel; Models, Molecular; mutation; potassium channels; Protein Conformation; Sequence Alignment; structure; voltage-dependent gating; K+ channel; drug-induced Long QT; hERG; voltage-dependent gating; inactivation; hERG block; cryo-EM; structure; K(+) channel