Metabolome Changes With Diet-Induced Remission in Pediatric Crohn’s Disease

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 163; no. 4; pp. 922 - 936.e15
• Main Authors: Ghiboub, Mohammed, Penny, Susanne, Verburgt, Charlotte M., Boneh, Rotem Sigall, Wine, Eytan, Cohen, Alejandro, Dunn, Katherine A., Pinto, Devanand M., Benninga, Marc A., de Jonge, Wouter J., Levine, Arie, Van Limbergen, Johan E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2022; Elsevier; American Gastroenterological Association
• Subjects: CDED+PEN; EEN; Metabolome; Metagenome; CD; RCT; KO; nr; Metabolome; LDA; CDED+PEN; AhR; IBD; PLS-DA; nsr; SCFA; EEN; AUC; PCA; LEfSe; FDR; W; PEN; rem; Metagenome; CDED; sr

The Crohn’s disease (CD) exclusion diet (CDED) plus partial enteral nutrition (PEN) and exclusive enteral nutrition (EEN) both induce remission in pediatric CD. CDED+PEN is better tolerated and able to sustain remission. We characterized the changes in fecal metabolites induced by CDED+PEN and EEN a...