2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

• Published in: Cell stem cell Vol. 18; no. 4; pp. 467 - 480
• Main Authors: Otani, Tomoki, Marchetto, Maria C., Gage, Fred H., Simons, Benjamin D., Livesey, Frederick J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.04.2016; Cell Press
• Subjects: Animals; Cell Cycle; Cell Differentiation; Cells, Cultured; Cerebral Cortex - anatomy & histology; Cerebral Cortex - cytology; Cerebral Cortex - growth & development; Humans; Models, Biological; Neurons - cytology; Organ Size; Organoids - cytology; Pluripotent Stem Cells - cytology; Primates - anatomy & histology; Species Specificity

Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed differentiation of pluripotent stem cells (PSCs) in adh...