Recruitment failure and futility were the most common reasons for discontinuation of clinical drug trials. Results of a nationwide inception cohort study in the Netherlands - van den Bogert, Cornelis A.; Souverein, Patrick C.; Brekelmans, Cecile T.M.; Janssen, Susan W.J.; Koëter, Gerard H.; Leufkens, Hubert G.M.; Bouter, Lex M. (Journal of clinical epidemiology, 2017)
Keywords: Cancer; Clinical Drug Development; Clinical trial; Clinical trials; Clinical Trials as Topic - statistics & numerical data; Clinical Trials Data Monitoring Committees; Cohort analysis; Cohort Studies; Data collection; Discontinuation; Drug development; Drug therapy; Early Termination of Clinical Trials - statistics & numerical data; Effectiveness; Epidemiology; Failure analysis; Feasibility studies; Futility; Human subjects; Humans; Interim analysis; Internal Medicine; Netherlands; Patient Selection; Pharmaceutical Preparations; Recruitment; Recruitment failure; Review boards; Sample Size; Studies; Recruitment failure; Interim analysis; Futility; Clinical trial; Discontinuation; Clinical Drug Development