Iron Homeostasis Regulates the Activity of the MicroRNA Pathway through Poly(C)-Binding Protein 2

• Published in: Cell metabolism Vol. 15; no. 6; pp. 895 - 904
• Main Authors: Li, Yujing, Lin, Li, Li, Zigang, Ye, Xuecheng, Xiong, Ke, Aryal, Baikuntha, Xu, Zihui, Paroo, Zain, Liu, Qinghua, He, Chuan, Jin, Peng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2012
• Subjects: 2,2'-Dipyridyl - pharmacology; Animals; biogenesis; chelating agents; DEAD-box RNA Helicases - metabolism; Deferoxamine - pharmacology; Enoxacin - pharmacology; gene expression; Gene Knockdown Techniques; Genes, Reporter; Green Fluorescent Proteins - biosynthesis; Green Fluorescent Proteins - genetics; HEK293 Cells; Homeostasis; Humans; iron; Iron - metabolism; Iron Chelating Agents - pharmacology; messenger RNA; Mice; microRNA; MicroRNAs - metabolism; NIH 3T3 Cells; Protein Multimerization; Ribonuclease III - metabolism; RNA Interference - drug effects; RNA Processing, Post-Transcriptional; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; translation (genetics)

MicroRNAs (miRNAs) control gene expression by promoting degradation or repressing translation of target mRNAs. The components of the miRNA pathway are subject to diverse modifications that can modulate the abundance and function of miRNAs. Iron is essential for fundamental metabolic processes, and i...