The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process

• Published in: The Journal of nutrition, health & aging Vol. 27; no. 4; pp. 291 - 300
• Main Authors: Abudahab, Sara, Price, E.T., Dozmorov, M.G., Deshpande, L.S., McClay, J.L.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.04.2023; Springer Paris; Springer Nature B.V
• Subjects: Aging; AhR ligands; aryl hydrocarbon receptors; data collection; Epigenesis, Genetic; Epigenetics; genetically modified organisms; Geriatrics/Gerontology; Humans; Hydrocarbons; Ligands; Liver - metabolism; longevity; Medicine; Medicine & Public Health; Metabolism; Neurosciences; Nutrition; Polychlorinated Dibenzodioxins - toxicity; Primary Care Medicine; Quality of Life Research; quercetin; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; resveratrol; Review; rodents; TCDD; Transcription factors; Xenobiotic metabolism; xenobiotics; Xenobiotics - metabolism; TCDD; Xenobiotic metabolism; quercetin; resveratrol; AhR ligands

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, classically associated with the regulation of xenobiotic metabolism in response to environmental toxins. In recent years, transgenic rodent models have implicated AhR in aging and longevity. Moreover, several AhR ligands...