Fibrillar vs crystalline nanocellulose pulmonary epithelial cell responses: Cytotoxicity or inflammation?

• Published in: Chemosphere (Oxford) Vol. 171; pp. 671 - 680
• Main Authors: Menas, Autumn L., Yanamala, Naveena, Farcas, Mariana T., Russo, Maria, Friend, Sherri, Fournier, Philip M., Star, Alexander, Iavicoli, Ivo, Shurin, Galina V., Vogel, Ulla B., Fadeel, Bengt, Beezhold, Donald, Kisin, Elena R., Shvedova, Anna A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2017
• Subjects: A549 Cells; carbon; Cell Survival - drug effects; cellulose; Cellulose - toxicity; chemokines; chitin; cluster analysis; Cytokine production; Cytokines - metabolism; cytotoxicity; Cytoxicity; epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Humans; immunomodulators; inflammation; Inflammation - metabolism; Lung - cytology; Lung epithelial cells; Nanocellulose; nanocrystals; nanofibers; Nanofibers - toxicity; Nanoparticles - toxicity; Oxidative stress; physicochemical properties; secretion; staining; stress response; Oxidative stress; Nanocellulose; Lung epithelial cells; Cytoxicity; Cytokine production

Nanocellulose (NC) is emerging as a highly promising nanomaterial for a wide range of applications. Moreover, many types of NC are produced, each exhibiting a slightly different shape, size, and chemistry. The main objective of this study was to compare cytotoxic effects of cellulose nanocrystals (C...