The influence of femtosecond laser intrastromal lenticules on the characteristics and maturity in tissue-engineered stem cell-derived retinal pigment epithelium sheets

• Published in: Stem cell research & therapy Vol. 16; no. 1; pp. 316 - 18
• Main Authors: Jianing, Gu, Zhanyu, Su, Yini, Wang, Yuexi, Chen, Zekai, Cui, Shengguo, Li, Chengcheng, Ding, Wang, Sheng, Kangjun, Li, Shibo, Tang, Jiansu, Chen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.06.2025; BioMed Central; BMC
• Subjects: Animals; Cell Differentiation; Cells, Cultured; Decellularization femtosecond laser intrastromal lenticule (dfLEN); Enzyme-linked immunosorbent assay; Epithelium; Ethylenediaminetetraacetic acid; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Lasers; Rabbits; Retinal Pigment Epithelium - cytology; Retinal Pigment Epithelium - metabolism; Stem cell-derived retinal pigment epithelium(iRPE); Stem cells; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Transplantation; China; Decellularization femtosecond laser intrastromal lenticule (dfLEN); Tissue engineering; Stem cell-derived retinal pigment epithelium(iRPE)

Recent advances in clinical trials have involved the transplantation of induced retinal pigment epithelium (iRPE) cells from stem cells in creating a functional monolayer that mimics the characteristics of natural adult RPE cells. One method of achieving this goal is through the use of tissue engine...