An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription - Mousseau, Guillaume; Clementz, Mark A.; Bakeman, Wendy N.; Nagarsheth, Nisha; Cameron, Michael; Shi, Jun; Baran, Phil; Fromentin, Rémi; Chomont, Nicolas; Valente, Susana T. (Cell host & microbe, 2012)
Keywords: alkaloids; Alkaloids - chemical synthesis; Alkaloids - chemistry; Alkaloids - pharmacokinetics; Alkaloids - pharmacology; Animals; Anti-HIV Agents - pharmacology; antiretroviral agents; Antiretroviral Therapy, Highly Active; Binding Sites; CD4-Positive T-Lymphocytes - virology; Cells, Cultured - drug effects; Cells, Cultured - virology; drugs; Female; gene expression; Gene Expression Regulation, Viral - drug effects; genome; Heterocyclic Compounds, 4 or More Rings - pharmacology; HIV Core Protein p24 - metabolism; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - physiology; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Humans; Isoquinolines - pharmacology; Male; messenger RNA; Mice; Mice, Inbred C57BL; Microsomes, Liver - drug effects; Polycyclic Compounds - chemistry; Porifera; Promoter Regions, Genetic; proviruses; Proviruses - drug effects; Proviruses - genetics; tat Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors; tat Gene Products, Human Immunodeficiency Virus - genetics; tat Gene Products, Human Immunodeficiency Virus - metabolism; therapeutics; transcription (genetics); Transcription, Genetic - drug effects; transcriptional activation; viremia; virion; Virus Replication - drug effects