Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

• Published in: Cell Vol. 160; no. 1-2; pp. 177 - 190
• Main Authors: Liu, Lucy, Zhang, Ke, Sandoval, Hector, Yamamoto, Shinya, Jaiswal, Manish, Sanz, Elisenda, Li, Zhihong, Hui, Jessica, Graham, Brett H., Quintana, Albert, Bellen, Hugo J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2015
• Subjects: Animals; binding proteins; carboxylic ester hydrolases; droplets; Drosophila; Electron Transport Complex I - genetics; Electron Transport Complex I - metabolism; Lipid Droplets - metabolism; lipid peroxidation; lipids; MAP Kinase Kinase 4 - metabolism; Mice; Mice, Knockout; mitochondria; Mitochondria - metabolism; mitogen-activated protein kinase; mutants; neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neuroglia - metabolism; Neuroglia - pathology; neurons; Neurons - pathology; reactive oxygen species; Reactive Oxygen Species - metabolism; Sterol Regulatory Element Binding Proteins - metabolism

Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here, we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (...