The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound

• Published in: Journal of controlled release Vol. 162; no. 1; pp. 134 - 142
• Main Authors: Park, Juyoung, Zhang, Yongzhi, Vykhodtseva, Natalia, Jolesz, Ferenc A., McDannold, Nathan J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 20.08.2012; Elsevier
• Subjects: Animals; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - pharmacokinetics; Biological and medical sciences; blood-brain barrier; Blood-Brain Barrier - metabolism; Blood–brain barrier disruption; brain; Brain - metabolism; Capillary Permeability; confidence interval; Contrast Media - administration & dosage; Contrast Media - analysis; doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - pharmacokinetics; Drug Delivery Systems - methods; drug therapy; Dynamic contrast enhanced MRI; Focused ultrasound; Gadolinium DTPA - administration & dosage; Gadolinium DTPA - analysis; General pharmacology; half life; intravenous injection; Magnetic Resonance Imaging; Male; Medical sciences; Microbubbles; Models, Biological; permeability; Pharmaceutical technology. Pharmaceutical industry; Pharmacokinetic model; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; Sonication - methods; ultrasonics; Dynamic contrast enhanced MRI; Focused ultrasound; Pharmacokinetic model; Blood–brain barrier disruption; Antineoplastic agent; DNA topoisomerase (ATP-hydrolysing); Pharmaceutical technology; Enzyme; Targeted therapy; Enzyme inhibitor; Topoisomerase II inhibitor; Permeability; Blood brain barrier; Doxorubicin; Nuclear magnetic resonance imaging; Encephalon; Antibiotic; Isomerases; Anthracyclins; Kinetics; Blood-brain barrier disruption; Pharmacokinetics; Ultrasound

Focused ultrasound (FUS) combined with a circulating microbubble agent is a promising strategy to non-invasively disrupt the blood–brain barrier (BBB) and could enable targeted delivery of therapeutics that normally do not leave the brain vasculature. This study investigated the kinetics of the BBB...