Identification of pheophorbide a as an inhibitor of receptor for advanced glycation end products in Mallotus japonicus

• Published in: Journal of Natural Medicines Vol. 75; no. 3; pp. 675 - 681
• Main Authors: Matsumoto, Teruki, Matsuno, Michiyo, Ikui, Norihito, Mizushina, Yoshiyuki, Omiya, Yume, Ishibashi, Rikako, Ueda, Taro, Mizukami, Hajime
• Format: Journal Article
• Language: English
• Published: Singapore Springer Science and Business Media LLC 01.06.2021; Springer Singapore; Springer Nature B.V
• Subjects: Advanced glycosylation end products; Antagonists; Biological products; Biomedical and Life Sciences; Biomedicine; Chlorophyll; Complementary & Alternative Medicine; diabetes; Diabetes mellitus; dietary supplements; Ethanol; Flowers & plants; fractionation; Functional foods & nutraceuticals; Glycation End Products, Advanced; Glycosylation; Humans; Japan; Leaves; Mallotus japonicus; Mallotus philippensis; Mallotus Plant; Medicinal Chemistry; Myanmar; Natural products; Neurodegenerative diseases; Pharmacology/Toxicology; Pharmacy; Phytochemicals; Plant extracts; Plant Leaves; Plant Sciences; Receptor for Advanced Glycation End Products; therapeutics; Myanmar; Advanced glycation end products; RAGE inhibitor; Receptor for advanced glycation end products; Pheophorbide a; Mallotus japonicus

Accumulation of advanced glycation end products (AGEs) plays an important role in diabetes, immunoinflammation, and cardiovascular and neurodegenerative diseases. Since AGEs mediate their pathological effects through interaction with receptor for AGEs (RAGE), RAGE antagonists would provide a useful...