Memantine reduces hematoma expansion in experimental intracerebral hemorrhage, resulting in functional improvement
Glutamate is accumulated in abundance during the early period of experimental hematoma, and the activation of N-methyl-D-aspartate (NMDA) receptors by glutamate can result in an influx of calcium and neuronal death in cases of intracerebral hemorrhage (ICH). Memantine, which is known to be a moderat...
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Published in | Journal of cerebral blood flow and metabolism Vol. 26; no. 4; pp. 536 - 544 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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London, England
SAGE Publications
01.04.2006
Lippincott Williams & Wilkins Sage Publications Ltd |
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Abstract | Glutamate is accumulated in abundance during the early period of experimental hematoma, and the activation of N-methyl-D-aspartate (NMDA) receptors by glutamate can result in an influx of calcium and neuronal death in cases of intracerebral hemorrhage (ICH). Memantine, which is known to be a moderate-affinity, uncompetitive, NMDA receptor antagonist, was investigated with regard to its ability to block the glutamate overstimulation and tissue plasminogen activator (tPA)/urokinase plasminogen activator (uPA)/matrix metalloproteinase (MMP)-9 modulation in experimental ICH. Intracerebral hemorrhage was induced via the infusion of collagenase into the left basal ganglia of adult rats. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered 30 min after the induction of ICH, and, at daily intervals afterwards, for either 3 or 14 days. Hemorrhage volume decreased by 47% in the memantine group, as compared with the ICH-only group. In the memantine group, the numbers of TUNEL+, myeloperoxidase (MPO)+, and OX42+ cells decreased in the periphery of the hematoma. Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation. Memantine also exerted a profound inhibitory effect on the upregulation of tPA/uPA mRNA, and finally decreased the MMP-9 level in the hemorrhagic brain. In modified limbplacing test, the memantine-treated rats exhibited lower scores initially, and recovered more quickly and thoroughly throughout the 35 days of the study. Here, we show that memantine causes a reduction of hematoma expansion, coupled with an inhibitory effect on the tPA/uPA and MMP-9 level. Subsequently, memantine was found to reduce inflammatory infiltration and apoptosis, and was also determined to induce functional recovery after ICH. |
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AbstractList | Glutamate is accumulated in abundance during the early period of experimental hematoma, and the activation of N-methyl-D-aspartate (NMDA) receptors by glutamate can result in an influx of calcium and neuronal death in cases of intracerebral hemorrhage (ICH). Memantine, which is known to be a moderate-affinity, uncompetitive, NMDA receptor antagonist, was investigated with regard to its ability to block the glutamate overstimulation and tissue plasminogen activator (tPA)/urokinase plasminogen activator (uPA)/matrix metalloproteinase (MMP)-9 modulation in experimental ICH. Intracerebral hemorrhage was induced via the infusion of collagenase into the left basal ganglia of adult rats. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered 30 min after the induction of ICH, and, at daily intervals afterwards, for either 3 or 14 days. Hemorrhage volume decreased by 47% in the memantine group, as compared with the ICH-only group. In the memantine group, the numbers of TUNEL+, myeloperoxidase (MPO)+, and OX42+ cells decreased in the periphery of the hematoma. Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation. Memantine also exerted a profound inhibitory effect on the upregulation of tPA/uPA mRNA, and finally decreased the MMP-9 level in the hemorrhagic brain. In modified limb-placing test, the memantine-treated rats exhibited lower scores initially, and recovered more quickly and thoroughly throughout the 35 days of the study. Here, we show that memantine causes a reduction of hematoma expansion, coupled with an inhibitory effect on the tPA/uPA and MMP-9 level. Subsequently, memantine was found to reduce inflammatory infiltration and apoptosis, and was also determined to induce functional recovery after ICH. Glutamate is accumulated in abundance during the early period of experimental hematoma, and the activation of N-methyl-D-aspartate (NMDA) receptors by glutamate can result in an influx of calcium and neuronal death in cases of intracerebral hemorrhage (ICH). Memantine, which is known to be a moderate-affinity, uncompetitive, NMDA receptor antagonist, was investigated with regard to its ability to block the glutamate overstimulation and tissue plasminogen activator (tPA)/urokinase plasminogen activator (uPA)/matrix metalloproteinase (MMP)-9 modulation in experimental ICH. Intracerebral hemorrhage was induced via the infusion of collagenase into the left basal ganglia of adult rats. Either memantine (20mg/kg/day) or PBS was intraperitoneally administered 30min after the induction of ICH, and, at daily intervals afterwards, for either 3 or 14 days. Hemorrhage volume decreased by 47% in the memantine group, as compared with the ICH-only group. In the memantine group, the numbers of TUNEL super(+), myeloperoxidase (MPO) super(+), and OX42 super(+) cells decreased in the periphery of the hematoma. Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation. Memantine also exerted a profound inhibitory effect on the upregulation of tPA/uPA mRNA, and finally decreased the MMP-9 level in the hemorrhagic brain. In modified limb-placing test, the memantine-treated rats exhibited lower scores initially, and recovered more quickly and thoroughly throughout the 35 days of the study. Here, we show that memantine causes a reduction of hematoma expansion, coupled with an inhibitory effect on the tPA/uPA and MMP-9 level. Subsequently, memantine was found to reduce inflammatory infiltration and apoptosis, and was also determined to induce functional recovery after ICH.Journal of Cerebral Blood Flow & Metabolism (2006) 26, 536-544. doi:10.1038/sj.jcbfm.9600213; published online 17 August 2005 Glutamate is accumulated in abundance during the early period of experimental hematoma, and the activation of N-methyl-D-aspartate (NMDA) receptors by glutamate can result in an influx of calcium and neuronal death in cases of intracerebral hemorrhage (ICH). Memantine, which is known to be a moderate-affinity, uncompetitive, NMDA receptor antagonist, was investigated with regard to its ability to block the glutamate overstimulation and tissue plasminogen activator (tPA)/urokinase plasminogen activator (uPA)/matrix metalloproteinase (MMP)-9 modulation in experimental ICH. Intracerebral hemorrhage was induced via the infusion of collagenase into the left basal ganglia of adult rats. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered 30 min after the induction of ICH, and, at daily intervals afterwards, for either 3 or 14 days. Hemorrhage volume decreased by 47% in the memantine group, as compared with the ICH-only group. In the memantine group, the numbers of TUNEL+, myeloperoxidase (MPO)+, and OX42+ cells decreased in the periphery of the hematoma. Memantine resulted in an upregulation of bcl-2 expression and an inhibition of caspase-3 activation. Memantine also exerted a profound inhibitory effect on the upregulation of tPA/uPA mRNA, and finally decreased the MMP-9 level in the hemorrhagic brain. In modified limbplacing test, the memantine-treated rats exhibited lower scores initially, and recovered more quickly and thoroughly throughout the 35 days of the study. Here, we show that memantine causes a reduction of hematoma expansion, coupled with an inhibitory effect on the tPA/uPA and MMP-9 level. Subsequently, memantine was found to reduce inflammatory infiltration and apoptosis, and was also determined to induce functional recovery after ICH. |
Author | Lee, Soon-Tae Kim, Manho Kim, Se-Jeong Sinn, Dong-In Kim, Eun-Hee Jung, Keun-Hwa Ko, Song-Yi Kim, Juhyun Roh, Jae-Kyu Chu, Kon |
Author_xml | – sequence: 1 givenname: Soon-Tae surname: Lee fullname: Lee, Soon-Tae – sequence: 2 givenname: Kon surname: Chu fullname: Chu, Kon – sequence: 3 givenname: Keun-Hwa surname: Jung fullname: Jung, Keun-Hwa – sequence: 4 givenname: Juhyun surname: Kim fullname: Kim, Juhyun – sequence: 5 givenname: Eun-Hee surname: Kim fullname: Kim, Eun-Hee – sequence: 6 givenname: Se-Jeong surname: Kim fullname: Kim, Se-Jeong – sequence: 7 givenname: Dong-In surname: Sinn fullname: Sinn, Dong-In – sequence: 8 givenname: Song-Yi surname: Ko fullname: Ko, Song-Yi – sequence: 9 givenname: Manho surname: Kim fullname: Kim, Manho – sequence: 10 givenname: Jae-Kyu surname: Roh fullname: Roh, Jae-Kyu email: rohjk@snu.ac.kr |
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Cites_doi | 10.1212/WNL.48.4.921 10.1161/01.STR.0000046458.67968.E4 10.1161/01.STR.0000131270.45822.85 10.1523/JNEUROSCI.2457-04.2004 10.1161/01.STR.29.6.1202 10.1161/01.STR.21.5.801 10.1097/00004647-200003000-00002 10.1172/JCI23977 10.1097/01.CCM.0000063047.63862.99 10.1038/nrn1106 10.1038/nm1204-1295 10.1038/nm926 10.1161/01.STR.0000143451.14228.ff 10.1097/00004647-200012000-00007 10.1093/brain/awh489 10.1016/S0304-3940(99)00682-5 10.1161/01.STR.0000096540.40826.BA 10.1161/01.STR.28.1.1 10.1161/01.STR.24.7.987 10.1016/S0028-3908(99)00019-2 10.1161/hs0302.104542 10.1161/01.STR.0000149615.51204.0b 10.1002/gps.939 10.1083/jcb.119.3.493 10.1523/JNEUROSCI.20-12-04582.2000 10.1161/01.STR.0000083698.20199.1F 10.1038/83358 10.1038/sj.jcbfm.9600070 10.1056/NEJMoa042991 10.1002/glia.20115 10.1038/nm1122 10.1016/0304-3940(96)12545-3 10.1016/S1474-4422(03)00486-1 10.1097/01.WCB.0000130866.25040.7D 10.1016/j.expneurol.2004.05.021 10.1161/01.STR.0000125855.17686.6d 10.1161/01.STR.28.11.2296 10.1097/00004647-200002000-00022 10.1016/j.brainres.2004.11.067 10.1038/sj.cdd.4401344 |
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Keywords | intracerebral hemorrhage tPA memantine MMP-9 glutamate Nervous system diseases Enzyme Cardiovascular disease Metalloendopeptidases Glutamate receptor Antialzheimer agent Glutamate Antiparkinson agent Gelatinase B Cerebral disorder Vascular disease Peptidases Memantine Cerebral hemorrhage Amantadine dérivatives Central nervous system disease Hematoma Hydrolases Antagonist NMDA receptor Cerebrovascular disease |
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References | Gavrieli, Y, Sherman, Y, Ben-Sasson, SA 1992; 119 Mayer, SA 2003; 34 Block, F, Schwarz, M 1996; 208 Parsons, CG, Danysz, W, Quack, G 1999; 38 Broderick, JP, Brott, TG, Duldner, JE, Tomsick, T, Huster, G 1993; 24 Sumii, T, Lo, EH 2002; 33 Wang, X, Lee, SR, Arai, K, Lee, SR, Tsuji, K, Rebeck, GW, Lo, EH 2003; 9 Asahi, M, Asahi, K, Jung, JC, del Zoppo, GJ, Fini, ME, Lo, EH 2000; 20 Culmsee, C, Junker, V, Kremers, W, Thal, S, Plesnila, N, Krieglstein, J 2004; 35 Jeong, SW, Chu, K, Jung, KH, Kim, SU, Kim, M, Roh, JK 2003; 34 Asahi, M, Asahi, K, Wang, X, Lo, EH 2000; 20 Wang, J, Tsirka, SE 2005 Ardizzone, TD, Lu, A, Wagner, KR, Tang, Y, Ran, R, Sharp, FR 2004; 35 Chu, K, Jeong, SW, Jung, KH, Han, SY, Lee, ST, Kim, M, Roh, JK 2004; 24 Rosenberg, GA, Mun-Bryce, S, Wesley, M, Kornfeld, M 1990; 21 Rosenberg, GA, Navratil, M 1997; 48 Shin, CY, Kundel, M, Wells, DG 2004; 24 Gravanis, I, Tsirka, SE 2005; 49 Wang, X, Asahi, M, Lo, EH 1999; 274 Liu, Z, Li, N, Diaz, LA, Shipley, JM, Senior, RM, Werb, Z 2005; 115 Liu, D, Cheng, T, Guo, H, Fernandez, JA, Griffin, JH, Song, X, Zlokovic, BV 2004; 10 Matsushita, K, Meng, W, Wang, X, Asahi, M, Asahi, K, Moskowitz, MA, Lo, EH 2000; 20 Möbius, HJ 2003; 18 Qureshi, AI, Ali, Z, Suri, MF, Shuaib, A, Baker, GA, Todd, K, Guterman, LR, Hopkins, LN 2003; 31 Maquoi, E, Munaut, C, Colige, A, Lambert, C, Frankenne, F, Noel, A, Grams, F, Krell, HW, Foidart, JM 2002; 15 Choudhri, TF, Hoh, BL, Solomon, RA, Connolly, ES, Pinsky, DJ 1997; 28 Jung, KH, Chu, K, Jeong, SW, Han, SY, Lee, ST, Kim, JY, Kim, M, Roh, JK 2004; 35 Thiex, R, Mayfrank, L, Rohde, V, Gilsbach, JM, Tsirka, SA 2004; 189 Lo, EH 2004; 10 Nicole, O, Docagne, F, Ali, C, Margaill, I, Carmeliet, P, MacKenzie, ET, Vivien, D, Buisson, A 2001; 7 Figueroa, BE, Keep, RF, Betz, AL, Hoff, JT 1998; 29 Park, HK, Chu, K, Lee, ST, Jung, KH, Kim, EH, Lee, KB, Song, YM, Jeong, SW, Kim, M, Roh, JK 2005; 1041 Lo, EH, Dalkara, T, Moskowitz, MA 2003; 4 Brott, T, Broderick, J, Kothari, R, Barsan, W, Tomsick, T, Sauerbeck, L, Spilker, J, Duldner, J, Khoury, J 1997; 28 Asahi, M, Huang, Z, Thomas, S, Yoshimura, SI, Sumii, T, Mori, T, Qiu, J, Amin-Hanjani, S, Huang, PL, Liao, JK, Lo, EH, Moskowitz, MA 2005; 25 Mayer, SA, Brun, NC, Begtrup, K, Broderick, J, Davis, S, Diringer, MN, Skolnicj, BE, Seiner, T 2005; 352 Gingrich, MB, Junge, CE, Lyuboslavsky, P, Traynelis, SF 2000; 20 Lee, SR, Lo, EH 2003; 34 Wilcock, GK 2003; 2 Silva, Y, Leira, R, Tejada, J, Lainez, JM, Castillo, J, Davalos, A 2005; 36 Lipton, SA, Chen, HS 2004; 11 Gravanis, Tsirka 2005; 49 Culmsee, Junker, Kremers, Thai, Plesnila, Krieglstein 2004; 35 Maquoi, Munaut, Colige, Lambert, Frankenne, Noel, Grams, Krell, Foidart 2002; 15 Asahi, Asahi, Jung, del Zoppo, Fini, Lo 2000a; 20 Figueroa, Keep, Betz, Hoff 1998; 29 Wang, Asahi, Lo 1999; 274 Matsushita, Meng, Wang, Asahi, Asahi, Moskowitz, Lo 2000; 20 Parsons, Danysz, Quack 1999; 38 Qureshi, Ali, Suri, Shuaib, Baker, Todd, Guterman, Hopkins 2003; 31 Thiex, Mayfrank, Rohde, Gilsbach, Tsirka 2004; 189 Sumii, Lo 2002; 33 Liu, Li, Diaz, Shipley, Senior, Werb 2005; 115 Park, Chu, Lee, Jung, Kim, Lee, Song, Jeong, Kim, Roh 2005; 1041 Lo 2004; 10 Mayer 2003; 34 Nicole, Docagne, Ali, Margaill, Carmeliet, MacKenzie, Vivien, Buisson 2001; 7 Gavrieli, Sherman, Ben-Sasson 1992; 119 Jung, Chu, Jeong, Han, Lee, Kim, Kim, Roh 2004; 35 Lo, Dalkara, Moskowitz 2003; 4 Ardizzone, Lu, Wagner, Tang, Ran, Sharp 2004; 35 Asahi, Asahi, Wang, Lo 2000b; 20 Liu, Cheng, Guo, Fernandez, Griffin, Song, Zlokovic 2004; 10 Choudhri, Hoh, Solomon, Connolly, Pinsky 1997; 28 Rosenberg, Navratil 1997; 48 Lipton, Chen 2004; 11 Wang, Lee, Arai, Lee, Tsuji, Rebeck, Lo 2003; 9 Chu, Jeong, Jung, Han, Lee, Kim, Roh 2004; 24 Rosenberg, Mun-Bryce, Wesley, Kornfeld 1990; 21 Shin, Kundel, Wells 2004; 24 Block, Schwarz 1996; 208 Gingrich, Junge, Lyuboslavsky, Traynelis 2000; 20 Möbius 2003; 18 Broderick, Brott, Duldner, Tomsick, Huster 1993; 24 Wilcock 2003; 2 Asahi, Huang, Thomas, Yoshimura, Sumii, Mori, Qiu, Amin-Hanjani, Huang, Liao, Lo, Moskowitz 2005; 25 Brott, Broderick, Kothari, Barsan, Tomsick, Sauerbeck, Spilker, Duldner, Khoury 1997; 28 Mayer, Brun, Begtrup, Broderick, Davis, Diringer, Skolnicj, Seiner 2005; 352 Lee, Lo 2003; 34 Jeong, Chu, Jung, Kim, Kim, Roh 2003; 34 2005; 36 bibr18-sj.jcbfm.9600213 bibr30-sj.jcbfm.9600213 bibr35-sj.jcbfm.9600213 bibr4-sj.jcbfm.9600213 bibr22-sj.jcbfm.9600213 bibr39-sj.jcbfm.9600213 bibr26-sj.jcbfm.9600213 bibr13-sj.jcbfm.9600213 bibr1-sj.jcbfm.9600213 bibr31-sj.jcbfm.9600213 bibr36-sj.jcbfm.9600213 bibr19-sj.jcbfm.9600213 bibr27-sj.jcbfm.9600213 bibr9-sj.jcbfm.9600213 bibr5-sj.jcbfm.9600213 bibr10-sj.jcbfm.9600213 bibr14-sj.jcbfm.9600213 bibr40-sj.jcbfm.9600213 bibr37-sj.jcbfm.9600213 bibr2-sj.jcbfm.9600213 bibr24-sj.jcbfm.9600213 bibr32-sj.jcbfm.9600213 bibr15-sj.jcbfm.9600213 Maquoi E (bibr23-sj.jcbfm.9600213) 2002; 15 bibr8-sj.jcbfm.9600213 bibr11-sj.jcbfm.9600213 bibr6-sj.jcbfm.9600213 bibr41-sj.jcbfm.9600213 bibr28-sj.jcbfm.9600213 bibr12-sj.jcbfm.9600213 bibr25-sj.jcbfm.9600213 bibr17-sj.jcbfm.9600213 bibr20-sj.jcbfm.9600213 bibr38-sj.jcbfm.9600213 bibr33-sj.jcbfm.9600213 bibr34-sj.jcbfm.9600213 bibr21-sj.jcbfm.9600213 bibr3-sj.jcbfm.9600213 bibr16-sj.jcbfm.9600213 bibr29-sj.jcbfm.9600213 bibr7-sj.jcbfm.9600213 |
References_xml | – volume: 36 start-page: 86 year: 2005 end-page: 91 article-title: Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage publication-title: Stroke contributor: fullname: Davalos, A – volume: 18 start-page: S47 year: 2003 end-page: 54 article-title: Memantine: update on the current evidence publication-title: Int J Geriatr Psychiatry contributor: fullname: Möbius, HJ – volume: 20 start-page: 1681 year: 2000 end-page: 1689 article-title: Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94 publication-title: J Cereb Blood Flow Metab contributor: fullname: Lo, EH – volume: 25 start-page: 722 year: 2005 end-page: 729 article-title: Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia publication-title: J Cereb Blood Flow Metab contributor: fullname: Moskowitz, MA – volume: 21 start-page: 801 year: 1990 end-page: 807 article-title: Collagenase-induced intracerebral hemorrhage in rats publication-title: Stroke contributor: fullname: Kornfeld, M – volume: 2 start-page: 503 year: 2003 end-page: 505 article-title: Memantine for the treatment of dementia publication-title: Lancet Neurol contributor: fullname: Wilcock, GK – volume: 35 start-page: 1744 year: 2004 end-page: 1749 article-title: HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage publication-title: Stroke contributor: fullname: Roh, JK – volume: 20 start-page: 396 year: 2000 end-page: 404 article-title: Evidence for apoptosis after intracerebral hemorrhage in rat striatum publication-title: J Cereb Blood Flow Metab contributor: fullname: Lo, EH – volume: 352 start-page: 777 year: 2005 end-page: 785 article-title: Recombinant activated factor VII for acute intracerebral hemorrhage publication-title: N Engl J Med contributor: fullname: Seiner, T – volume: 9 start-page: 1313 year: 2003 end-page: 1317 article-title: Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator publication-title: Nat Med contributor: fullname: Lo, EH – volume: 48 start-page: 921 year: 1997 end-page: 926 article-title: Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat publication-title: Neurology contributor: fullname: Navratil, M – volume: 24 start-page: 987 year: 1993 end-page: 993 article-title: Volume of intracerebral hemorrhage: a powerful and easy-to-use predictor of 30-day mortality publication-title: Stroke contributor: fullname: Huster, G – volume: 28 start-page: 2296 year: 1997 end-page: 2302 article-title: Use of a spectrophotometric assay to objectively quantify intracerebral hemorrhage in mice publication-title: Stroke contributor: fullname: Pinsky, DJ – volume: 33 start-page: 831 year: 2002 end-page: 836 article-title: Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats publication-title: Stroke contributor: fullname: Lo, EH – volume: 34 start-page: 2258 year: 2003 end-page: 2263 article-title: Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage publication-title: Stroke contributor: fullname: Roh, JK – volume: 34 start-page: 2704 year: 2003 end-page: 2709 article-title: Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation publication-title: Stroke contributor: fullname: Lo, EH – volume: 189 start-page: 25 year: 2004 end-page: 32 article-title: The role of endogenous versus exogenous tPA on edema formation in murine ICH publication-title: Exp Neurol contributor: fullname: Tsirka, SA – volume: 10 start-page: 1295 year: 2004 end-page: 1296 article-title: Combination stroke therapy: easy as APC? publication-title: Nat Med contributor: fullname: Lo, EH – volume: 119 start-page: 493 year: 1992 end-page: 501 article-title: Identification of programmed cell death via specific labeling of nuclear DNA fragmentation publication-title: J Cell Biol contributor: fullname: Ben-Sasson, SA – volume: 208 start-page: 41 year: 1996 end-page: 44 article-title: Memantine reduces functional and morphological consequences induced by global ischemia in rats publication-title: Neurosci Lett contributor: fullname: Schwarz, M – volume: 28 start-page: 1 year: 1997 end-page: 5 article-title: Early hemorrhage growth in patients with intracerebral hemorrhage publication-title: Stroke contributor: fullname: Khoury, J – volume: 24 start-page: 926 year: 2004 end-page: 933 article-title: Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death publication-title: J Cereb Blood Flow Metab contributor: fullname: Roh, JK – volume: 20 start-page: 452 year: 2000 end-page: 457 article-title: Reduction of tissue plasminogen activator induced hemorrhage and brain injury by free radical spin trapping after focal cerebral ischemia in rats publication-title: J Cereb Blood Flow Metab contributor: fullname: Lo, EH – volume: 115 start-page: 879 year: 2005 end-page: 887 article-title: Synergy between a plasminogen cascade and MMP-9 in autoimmune disease publication-title: J Clin Invest contributor: fullname: Werb, Z – volume: 7 start-page: 59 year: 2001 end-page: 64 article-title: The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling publication-title: Nat Med contributor: fullname: Buisson, A – year: 2005 article-title: Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage publication-title: Brain contributor: fullname: Tsirka, SE – volume: 35 start-page: 1197 year: 2004 end-page: 1202 article-title: Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol publication-title: Stroke contributor: fullname: Krieglstein, J – volume: 35 start-page: 2587 year: 2004 end-page: 2591 article-title: Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat publication-title: Stroke contributor: fullname: Sharp, FR – volume: 10 start-page: 1379 year: 2004 end-page: 1383 article-title: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C publication-title: Nat Med contributor: fullname: Zlokovic, BV – volume: 11 start-page: 18 year: 2004 end-page: 20 article-title: Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine publication-title: Cell Death Differ contributor: fullname: Chen, HS – volume: 1041 start-page: 125 year: 2005 end-page: 131 article-title: Granulocyte colony-stimulating factor induces sensorimotor recovery in intracerebral hemorrhage publication-title: Brain Res contributor: fullname: Roh, JK – volume: 31 start-page: 1482 year: 2003 end-page: 1489 article-title: Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an microdialysis study publication-title: Crit Care Med contributor: fullname: Hopkins, LN – volume: 24 start-page: 9425 year: 2004 end-page: 9433 article-title: Rapid, activity-induced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation publication-title: J Neurosci contributor: fullname: Wells, DG – volume: 34 start-page: 224 year: 2003 end-page: 229 article-title: Ultra-early hemostatic therapy for intracerebral hemorrhage publication-title: Stroke contributor: fullname: Mayer, SA – volume: 38 start-page: 735 year: 1999 end-page: 767 article-title: Memantine is a clinically well tolerated -methyl- -aspartate (NMDA) receptor antagonist-a review of preclinical data publication-title: Neuropharmacology contributor: fullname: Quack, G – volume: 29 start-page: 1202 year: 1998 end-page: 1207 article-title: Plasminogen activators potentiate thrombin-induced brain injury publication-title: Stroke contributor: fullname: Hoff, JT – volume: 274 start-page: 79 year: 1999 end-page: 82 article-title: Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures publication-title: Neurosci Lett contributor: fullname: Lo, EH – volume: 49 start-page: 177 year: 2005 end-page: 183 article-title: Tissue plasminogen activator and glial function publication-title: Glia contributor: fullname: Tsirka, SE – volume: 4 start-page: 399 year: 2003 end-page: 415 article-title: Mechanisms, challenges and opportunities in stroke publication-title: Nat Rev Neurosci contributor: fullname: Moskowitz, MA – volume: 20 start-page: 4582 year: 2000 end-page: 4595 article-title: Potentiation of NMDA receptor function by the serine protease thrombin publication-title: J Neurosci contributor: fullname: Traynelis, SF – volume: 15 start-page: 275:110 year: 2002 end-page: 275:121 article-title: Stimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors publication-title: Exp Cell Res contributor: fullname: Foidart, JM – volume: 29 start-page: 1202 year: 1998 end-page: 7 article-title: Plasminogen activators potentiate thrombin-induced brain injury publication-title: Stroke contributor: fullname: Hoff – volume: 20 start-page: 396 year: 2000 end-page: 404 article-title: Evidence for apoptosis after intracerebral hemorrhage in rat striatum publication-title: J Cereb Blood Flow Metab contributor: fullname: Lo – volume: 115 start-page: 879 year: 2005 end-page: 87 article-title: Synergy between a plasminogen cascade and MMP-9 in autoimmune disease publication-title: J Clin Invest contributor: fullname: Werb – volume: 20 start-page: 452 year: 2000b end-page: 7 article-title: Reduction of tissue plasminogen activator induced hemorrhage and brain injury by free radical spin trapping after focal cerebral ischemia in rats publication-title: J Cereb Blood Flow Metab contributor: fullname: Lo – volume: 38 start-page: 735 year: 1999 end-page: 67 article-title: Memantine is a clinically well tolerated -methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data publication-title: Neuropharmacology contributor: fullname: Quack – volume: 15 start-page: 275 110 year: 2002 end-page: 21 article-title: Stimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors publication-title: Exp Cell Res contributor: fullname: Foidart – volume: 1041 start-page: 125 year: 2005 end-page: 31 article-title: Granulocyte colony-stimulating factor induces sensorimotor recovery in intracerebral hemorrhage publication-title: Brain Res contributor: fullname: Roh – volume: 119 start-page: 493 year: 1992 end-page: 501 article-title: Identification of programmed cell death via specific labeling of nuclear DNA fragmentation publication-title: J Cell Biol contributor: fullname: Ben-Sasson – volume: 20 start-page: 4582 year: 2000 end-page: 95 article-title: Potentiation of NMDA receptor function by the serine protease thrombin publication-title: J Neurosci contributor: fullname: Traynelis – volume: 7 start-page: 59 year: 2001 end-page: 64 article-title: The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling publication-title: Nat Med contributor: fullname: Buisson – volume: 25 start-page: 722 year: 2005 end-page: 9 article-title: Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia publication-title: J Cereb Blood Flow Metab contributor: fullname: Moskowitz – volume: 2 start-page: 503 year: 2003 end-page: 5 article-title: Memantine for the treatment of dementia publication-title: Lancet Neurol contributor: fullname: Wilcock – volume: 49 start-page: 177 year: 2005 end-page: 83 article-title: Tissue plasminogen activator and glial function publication-title: Glia contributor: fullname: Tsirka – volume: 20 start-page: 1681 year: 2000a end-page: 9 article-title: Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94 publication-title: J Cereb Blood Flow Metab contributor: fullname: Lo – volume: 4 start-page: 399 year: 2003 end-page: 415 article-title: Mechanisms, challenges and opportunities in stroke publication-title: Nat Rev Neurosci contributor: fullname: Moskowitz – volume: 24 start-page: 987 year: 1993 end-page: 93 article-title: Volume of intracerebral hemorrhage: a powerful and easy-to-use predictor of 30-day mortality publication-title: Stroke contributor: fullname: Huster – volume: 31 start-page: 1482 year: 2003 end-page: 9 article-title: Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an microdialysis study publication-title: Crit Care Med contributor: fullname: Hopkins – volume: 34 start-page: 224 year: 2003 end-page: 9 article-title: Ultra-early hemostatic therapy for intracerebral hemorrhage publication-title: Stroke contributor: fullname: Mayer – volume: 35 start-page: 1197 year: 2004 end-page: 202 article-title: Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol publication-title: Stroke contributor: fullname: Krieglstein – volume: 34 start-page: 2704 year: 2003 end-page: 9 article-title: Interactions between p38 mitogenactivated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation publication-title: Stroke contributor: fullname: Lo – volume: 189 start-page: 25 year: 2004 end-page: 32 article-title: The role of endogenous versus exogenous tPA on edema formation in murine ICH publication-title: Exp Neurol contributor: fullname: Tsirka – volume: 35 start-page: 2587 year: 2004 end-page: 91 article-title: Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in rat publication-title: Stroke contributor: fullname: Sharp – volume: 24 start-page: 926 year: 2004 end-page: 33 article-title: Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death publication-title: J Cereb Blood Flow Metab contributor: fullname: Roh – volume: 10 start-page: 1379 year: 2004 end-page: 83 article-title: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C publication-title: Nat Med contributor: fullname: Zlokovic – volume: 10 start-page: 1295 year: 2004 end-page: 6 article-title: Combination stroke therapy: easy as APC? publication-title: Nat Med contributor: fullname: Lo – volume: 274 start-page: 79 year: 1999 end-page: 82 article-title: Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures publication-title: Neurosci Lett contributor: fullname: Lo – volume: 208 start-page: 41 year: 1996 end-page: 4 article-title: Memantine reduces functional and morphological consequences induced by global ischemia in rats publication-title: Neurosci Lett contributor: fullname: Schwarz – volume: 48 start-page: 921 year: 1997 end-page: 6 article-title: Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat publication-title: Neurology contributor: fullname: Navratil – volume: 24 start-page: 9425 year: 2004 end-page: 33 article-title: Rapid, activityinduced increase in tissue plasminogen activator is mediated by metabotropic glutamate receptor-dependent mRNA translation publication-title: J Neurosci contributor: fullname: Wells – volume: 36 start-page: 86 year: 2005 end-page: 91 article-title: Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage publication-title: Stroke – volume: 28 start-page: 2296 year: 1997 end-page: 302 article-title: Use of a spectrophotometric assay to objectively quantify intracerebral hemorrhage in mice publication-title: Stroke contributor: fullname: Pinsky – volume: 21 start-page: 801 year: 1990 end-page: 7 article-title: Collagenase-induced intracerebral hemorrhage in rats publication-title: Stroke contributor: fullname: Kornfeld – volume: 9 start-page: 1313 year: 2003 end-page: 7 article-title: Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator publication-title: Nat Med contributor: fullname: Lo – volume: 34 start-page: 2258 year: 2003 end-page: 63 article-title: Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage publication-title: Stroke contributor: fullname: Roh – volume: 33 start-page: 831 year: 2002 end-page: 6 article-title: Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats publication-title: Stroke contributor: fullname: Lo – volume: 28 start-page: 1 year: 1997 end-page: 5 article-title: Early hemorrhage growth in patients with intracerebral hemorrhage publication-title: Stroke contributor: fullname: Khoury – volume: 18 start-page: S47 year: 2003 end-page: 54 article-title: Memantine: update on the current evidence publication-title: Int J Geriatr Psychiatry contributor: fullname: Möbius – volume: 352 start-page: 777 year: 2005 end-page: 85 article-title: Recombinant activated factor VII for acute intracerebral hemorrhage publication-title: N Engl J Med contributor: fullname: Seiner – volume: 35 start-page: 1744 year: 2004 end-page: 9 article-title: HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage publication-title: Stroke contributor: fullname: Roh – volume: 11 start-page: 18 year: 2004 end-page: 20 article-title: Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine publication-title: Cell Death Differ contributor: fullname: Chen – ident: bibr33-sj.jcbfm.9600213 doi: 10.1212/WNL.48.4.921 – ident: bibr25-sj.jcbfm.9600213 doi: 10.1161/01.STR.0000046458.67968.E4 – ident: bibr16-sj.jcbfm.9600213 doi: 10.1161/01.STR.0000131270.45822.85 – ident: bibr34-sj.jcbfm.9600213 doi: 10.1523/JNEUROSCI.2457-04.2004 – ident: bibr11-sj.jcbfm.9600213 doi: 10.1161/01.STR.29.6.1202 – ident: bibr32-sj.jcbfm.9600213 doi: 10.1161/01.STR.21.5.801 – ident: bibr3-sj.jcbfm.9600213 doi: 10.1097/00004647-200003000-00002 – ident: bibr20-sj.jcbfm.9600213 doi: 10.1172/JCI23977 – ident: bibr31-sj.jcbfm.9600213 doi: 10.1097/01.CCM.0000063047.63862.99 – ident: bibr22-sj.jcbfm.9600213 doi: 10.1038/nrn1106 – volume: 15 start-page: 275 year: 2002 ident: bibr23-sj.jcbfm.9600213 publication-title: Exp Cell Res contributor: fullname: Maquoi E – ident: bibr21-sj.jcbfm.9600213 doi: 10.1038/nm1204-1295 – ident: bibr40-sj.jcbfm.9600213 doi: 10.1038/nm926 – ident: bibr1-sj.jcbfm.9600213 doi: 10.1161/01.STR.0000143451.14228.ff – ident: bibr2-sj.jcbfm.9600213 doi: 10.1097/00004647-200012000-00007 – ident: bibr38-sj.jcbfm.9600213 doi: 10.1093/brain/awh489 – ident: bibr39-sj.jcbfm.9600213 doi: 10.1016/S0304-3940(99)00682-5 – ident: bibr17-sj.jcbfm.9600213 doi: 10.1161/01.STR.0000096540.40826.BA – ident: bibr7-sj.jcbfm.9600213 doi: 10.1161/01.STR.28.1.1 – ident: bibr6-sj.jcbfm.9600213 doi: 10.1161/01.STR.24.7.987 – ident: bibr30-sj.jcbfm.9600213 doi: 10.1016/S0028-3908(99)00019-2 – ident: bibr36-sj.jcbfm.9600213 doi: 10.1161/hs0302.104542 – ident: bibr35-sj.jcbfm.9600213 doi: 10.1161/01.STR.0000149615.51204.0b – ident: bibr27-sj.jcbfm.9600213 doi: 10.1002/gps.939 – ident: bibr12-sj.jcbfm.9600213 doi: 10.1083/jcb.119.3.493 – ident: bibr13-sj.jcbfm.9600213 doi: 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SubjectTerms | Animals Biological and medical sciences Cerebral Hemorrhage - drug therapy Disease Models, Animal Drug toxicity and drugs side effects treatment Gene Expression Regulation - drug effects Hematoma - drug therapy Male Matrix Metalloproteinases - analysis Medical sciences Memantine - administration & dosage Memantine - pharmacology Neurology Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Rats Rats, Sprague-Dawley RNA, Messenger - genetics Tissue Plasminogen Activator - genetics Toxicity: nervous system and muscle Treatment Outcome Urokinase-Type Plasminogen Activator - genetics Vascular diseases and vascular malformations of the nervous system |
Title | Memantine reduces hematoma expansion in experimental intracerebral hemorrhage, resulting in functional improvement |
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