SARS-CoV-2-specific CD4+ T cell longevity correlates with Th17-like phenotype

Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyze...

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Published iniScience Vol. 25; no. 9; p. 104959
Main Authors Terahara, Kazutaka, Sato, Takashi, Adachi, Yu, Tonouchi, Keisuke, Onodera, Taishi, Moriyama, Saya, Sun, Lin, Takano, Tomohiro, Nishiyama, Ayae, Kawana-Tachikawa, Ai, Matano, Tetsuro, Matsumura, Takayuki, Shinkai, Masaharu, Isogawa, Masanori, Takahashi, Yoshimasa
Format Journal Article
LanguageEnglish
Published Elsevier Inc 16.09.2022
Elsevier
Subjects
Biological sciences
Health sciences
Immunology
Medicine
Virology
Medicine
Health sciences
Biological sciences
Immunology
Virology
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Abstract Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses. [Display omitted] •Th17-like CD4+ T cells showed a longer half-life than other CD4+ T cell subsets•Anti-RBD-IgG titers were associated with Th2- and Tfh-like CD4 T cells•CD45RA+CD8+ T cells were correlated with disease severity during the early phase Health sciences; Medicine; Immunology; Virology; Biological sciences; Immunology; Virology.
AbstractList Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4 + and CD8 + T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4 + T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4 + T cell subsets are associated with longevity and antibody responses. • Th17-like CD4 + T cells showed a longer half-life than other CD4 + T cell subsets • Anti-RBD-IgG titers were associated with Th2- and Tfh-like CD4 T cells • CD45RA+CD8 + T cells were correlated with disease severity during the early phase Health sciences; Medicine; Immunology; Virology; Biological sciences; Immunology; Virology.
Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses.Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses.
Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses.
Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses. [Display omitted] •Th17-like CD4+ T cells showed a longer half-life than other CD4+ T cell subsets•Anti-RBD-IgG titers were associated with Th2- and Tfh-like CD4 T cells•CD45RA+CD8+ T cells were correlated with disease severity during the early phase Health sciences; Medicine; Immunology; Virology; Biological sciences; Immunology; Virology.
ArticleNumber 104959
Author Shinkai, Masaharu
Onodera, Taishi
Terahara, Kazutaka
Adachi, Yu
Moriyama, Saya
Tonouchi, Keisuke
Takahashi, Yoshimasa
Isogawa, Masanori
Kawana-Tachikawa, Ai
Matano, Tetsuro
Matsumura, Takayuki
Sun, Lin
Nishiyama, Ayae
Sato, Takashi
Takano, Tomohiro
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  organization: Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
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  givenname: Keisuke
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  surname: Kawana-Tachikawa
  fullname: Kawana-Tachikawa, Ai
  organization: AIDS Research Center, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan
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  fullname: Matano, Tetsuro
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– sequence: 12
  givenname: Takayuki
  surname: Matsumura
  fullname: Matsumura, Takayuki
  organization: Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
– sequence: 13
  givenname: Masaharu
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  givenname: Masanori
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  surname: Isogawa
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  email: nisogawa@niid.go.jp
  organization: Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
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  givenname: Yoshimasa
  surname: Takahashi
  fullname: Takahashi, Yoshimasa
  email: ytakahas@niid.go.jp
  organization: Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
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Cites_doi 10.1084/jem.20202617
10.1126/science.abc8511
10.1016/j.immuni.2021.07.008
10.1016/j.cell.2020.10.001
10.1016/j.cell.2020.08.017
10.1371/journal.ppat.1009761
10.1038/nri.2015.18
10.1016/j.cell.2020.12.015
10.1016/j.immuni.2010.12.012
10.1038/s41421-021-00250-9
10.1016/j.immuni.2008.04.018
10.1126/science.abh1823
10.1038/s41467-020-17292-4
10.1016/j.chom.2021.06.006
10.1038/s41467-021-21444-5
10.1126/sciimmunol.abl9105
10.1038/ni.2038
10.1038/s41392-020-00301-9
10.1002/eji.200636251
10.1002/eji.202049046
10.1016/j.immuni.2021.04.006
10.1016/j.cell.2020.09.037
10.1016/j.celrep.2021.108728
10.1016/S1074-7613(00)80583-X
10.7883/yoken.JJID.2005.88
10.1038/s41586-020-2598-9
10.1126/science.abc5902
10.1038/s41586-020-2456-9
10.1038/ni.3054
10.1016/j.cell.2020.05.015
10.1016/S0140-6736(21)02758-6
10.7554/eLife.57063
10.1038/s41586-020-2550-z
10.1038/s41586-021-03207-w
10.1038/44385
10.1126/science.abf4063
10.1016/j.immuni.2021.06.015
10.1038/s41591-020-0995-0
10.1016/j.cell.2021.01.007
10.1038/s41586-021-03696-9
10.1126/sciimmunol.aan5393
10.1038/s41467-021-24377-1
10.4049/jimmunol.0903490
10.1038/nri3803
10.1038/s41591-020-0897-1
10.1084/jem.194.12.1711
10.1016/j.cell.2020.11.029
10.1084/jem.20071397
10.1016/j.cell.2020.09.038
10.4049/jimmunol.180.1.214
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References Boppana, Qin, Files, Russell, Stoltz, Bibollet-Ruche, Bansal, Erdmann, Hahn, Goepfert (bib4) 2021; 17
Juno, Tan, Lee, Reynaldi, Kelly, Wragg, Esterbauer, Kent, Batten, Mordant (bib17) 2020; 26
Sekine, Perez-Potti, Rivera-Ballesteros, Strålin, Gorin, Olsson, Llewellyn-Lacey, Kamal, Bogdanovic, Muschiol (bib40) 2020; 183
Brouwer, Caniels, Straten, van der, Snitselaar, Aldon, Bangaru, Torres, Okba, Claireaux, Kerster (bib51) 2020; 369
Ohnishi, Sakaguchi, Kaji, Akagawa, Taniyama, Kasai, Tsunetsugu-Yokota, Oshima, Yamamoto, Takasuka (bib52) 2005; 58
Jung, Rha, Sa, Choi, Jeon, Seok, Park, Park, Jeong, Choi, Shin (bib16) 2021; 12
Dan, Mateus, Kato, Hastie, Yu, Faliti, Grifoni, Ramirez, Haupt, Frazier (bib9) 2021; 371
Motozono, Toyoda, Zahradnik, Saito, Nasser, Tan, Ngare, Kimura, Uriu, Kosugi (bib30) 2021; 29
Ward, Bacon, Westwick (bib48) 1998; 9
Zhao, Alshukairi, Baharoon, Ahmed, Bokhari, Nehdi, Layqah, Alghamdi, Al Gethamy, Dada (bib50) 2017; 2
Morita, Schmitt, Bentebibel, Ranganathan, Bourdery, Zurawski, Foucat, Dullaers, Oh, Sabzghabaei (bib28) 2011; 34
Gaebler, Wang, Lorenzi, Muecksch, Finkin, Tokuyama, Cho, Jankovic, Schaefer-Babajew, Oliveira (bib11) 2021; 591
Grifoni, Weiskopf, Ramirez, Mateus, Dan, Moderbacher, Rawlings, Sutherland, Premkumar, Jadi (bib14) 2020; 181
Pepper, Jenkins (bib33) 2011; 12
Le Bert, Tan, Kunasegaran, Tham, Hafezi, Chia, Chng, Lin, Tan, Linster (bib1) 2020; 584
Chen, Pan, Yue, Yu, Zhang, Yang, Li, Liu, Yang, Gao (bib7) 2020; 5
Wheatley, Juno, Wang, Selva, Reynaldi, Tan, Lee, Wragg, Kelly, Esterbauer (bib49) 2021; 12
Cele, Jackson, Khan, Khoury, Moyo-Gwete, Tegally, Scheepers, Amoako, Karim, Bernstein (bib6) 2021
Karim, Karim (bib18) 2021; 398
Loyal, Braun, Henze, Kruse, Dingeldey, Reimer, Kern, Schwarz, Mangold, Unger (bib24) 2021; 374
Kasatskaya, Ladell, Egorov, Miners, Davydov, Metsger, Staroverov, Matveyshina, Shagina, Mamedov (bib19) 2020; 9
Muecksch, Weisblum, Barnes, Schmidt, Schaefer-Babajew, Wang, C Lorenzi, Flyak, DeLaitsch, Huey-Tubman (bib31) 2021; 54
Nemet, Kliker, Lustig, Zuckerman, Erster, Cohen, Kreiss, Alroy-Preis, Regev-Yochay, Mendelson (bib32) 2021
Garcia-Beltran, Lam, Astudillo, Yang, Miller, Feldman, Hauser, Caradonna, Clayton, Nitido (bib12) 2021; 184
Sallusto, Lenig, Förster, Lipp, Lanzavecchia (bib38) 1999; 401
Geginat, Sallusto, Lanzavecchia (bib13) 2001; 194
Kondo, Takata, Takiguchi (bib20) 2007; 37
Sette, Moutaftsi, Moyron-Quiroz, McCausland, Davies, Johnston, Peters, Rafii-El-Idrissi Benhnia, Hoffmann, Su (bib42) 2008; 28
Hirota, Yoshitomi, Hashimoto, Maeda, Teradaira, Sugimoto, Yamaguchi, Nomura, Ito, Nakamura (bib15) 2007; 204
Mathew, Giles, Baxter, Oldridge, Greenplate, Wu, Alanio, Kuri-Cervantes, Pampena, D’Andrea (bib25) 2020; 369
Tang, Quan, Xin, Wrammert, Ma, Lv, Wang, Yang, Richardus, Liu, Cao (bib45) 2011; 186
Ueno, Banchereau, Vinuesa (bib46) 2015; 16
Sette, Crotty (bib41) 2021; 184
Lineburg, Grant, Swaminathan, Chatzileontiadou, Szeto, Sloane, Panikkar, Raju, Crooks, Rehan (bib21) 2021; 54
Long, Jia, Wang, Deng, Cao, Yuan, Fang, Cheng, Luo, He (bib23) 2021; 7
Braun, Loyal, Frentsch, Wendisch, Georg, Kurth, Hippenstiel, Dingeldey, Kruse, Fauchere (bib5) 2020; 587
Tan, Linster, Tan, Le Bert, Chia, Kunasegaran, Zhuang, Tham, Chia, Smith (bib44) 2021; 34
Saris, Reijnders, Reijm, Hollander, de Buck, Schuurman, Duitman, Heunks, Aman, Bogaard (bib39) 2021; 51
Long, Liu, Deng, Wu, Deng, Chen, Liao, Qiu, Lin, Cai (bib22) 2020; 26
Robbiani, Gaebler, Muecksch, Lorenzi, Wang, Cho, Agudelo, Barnes, Gazumyan, Finkin (bib36) 2020; 584
Rydyznski Moderbacher, Ramirez, Dan, Grifoni, Hastie, Weiskopf, Belanger, Abbott, Kim, Choi (bib27) 2020; 183
Poon, Rybkina, Kato, Kubota, Matsumoto, Bloom, Zhang, Hastie, Grifoni, Weiskopf (bib35) 2021; 6
Crotty (bib8) 2015; 15
DuPage, Bluestone (bib10) 2016; 16
Le Bert, Clapham, Tan, Chia, Tham, Lim, Kunasegaran, Tan, Dutertre, Shankar (bib2) 2021; 218
Rodda, Netland, Shehata, Pruner, Morawski, Thouvenel, Takehara, Eggenberger, Hemann, Waterman (bib37) 2021; 184
De Biasi, Meschiari, Gibellini, Bellinazzi, Borella, Fidanza, Gozzi, Iannone, Lo Tartaro, Mattioli (bib3) 2020; 11
Meckiff, Ramírez-Suástegui, Fajardo, Chee, Kusnadi, Simon, Eschweiler, Grifoni, Pelosi, Weiskopf (bib26) 2020; 183
Singh, Zhang, Foley, Hedrick, Farber (bib43) 2008; 180
Wang, Muecksch, Schaefer-Babajew, Finkin, Viant, Gaebler, Hoffmann, Barnes, Cipolla, Ramos (bib47) 2021; 595
Moriyama, Adachi, Sato, Tonouchi, Sun, Fukushi, Yamada, Kinoshita, Nojima, Kanno (bib29) 2021; 54
Piccoli, Park, Tortorici, Czudnochowski, Walls, Beltramello, Silacci-Fregni, Pinto, Rosen, Bowen (bib34) 2020; 183
Motozono (10.1016/j.isci.2022.104959_bib30) 2021; 29
Sette (10.1016/j.isci.2022.104959_bib41) 2021; 184
Grifoni (10.1016/j.isci.2022.104959_bib14) 2020; 181
Cele (10.1016/j.isci.2022.104959_bib6) 2021
Sette (10.1016/j.isci.2022.104959_bib42) 2008; 28
Rodda (10.1016/j.isci.2022.104959_bib37) 2021; 184
Tang (10.1016/j.isci.2022.104959_bib45) 2011; 186
Le Bert (10.1016/j.isci.2022.104959_bib2) 2021; 218
Ward (10.1016/j.isci.2022.104959_bib48) 1998; 9
Kasatskaya (10.1016/j.isci.2022.104959_bib19) 2020; 9
Piccoli (10.1016/j.isci.2022.104959_bib34) 2020; 183
Robbiani (10.1016/j.isci.2022.104959_bib36) 2020; 584
Moriyama (10.1016/j.isci.2022.104959_bib29) 2021; 54
Garcia-Beltran (10.1016/j.isci.2022.104959_bib12) 2021; 184
Geginat (10.1016/j.isci.2022.104959_bib13) 2001; 194
Long (10.1016/j.isci.2022.104959_bib22) 2020; 26
Wheatley (10.1016/j.isci.2022.104959_bib49) 2021; 12
Gaebler (10.1016/j.isci.2022.104959_bib11) 2021; 591
Hirota (10.1016/j.isci.2022.104959_bib15) 2007; 204
Jung (10.1016/j.isci.2022.104959_bib16) 2021; 12
Boppana (10.1016/j.isci.2022.104959_bib4) 2021; 17
Nemet (10.1016/j.isci.2022.104959_bib32) 2021
Wang (10.1016/j.isci.2022.104959_bib47) 2021; 595
Braun (10.1016/j.isci.2022.104959_bib5) 2020; 587
Pepper (10.1016/j.isci.2022.104959_bib33) 2011; 12
De Biasi (10.1016/j.isci.2022.104959_bib3) 2020; 11
Ohnishi (10.1016/j.isci.2022.104959_bib52) 2005; 58
Singh (10.1016/j.isci.2022.104959_bib43) 2008; 180
Zhao (10.1016/j.isci.2022.104959_bib50) 2017; 2
Meckiff (10.1016/j.isci.2022.104959_bib26) 2020; 183
Saris (10.1016/j.isci.2022.104959_bib39) 2021; 51
Mathew (10.1016/j.isci.2022.104959_bib25) 2020; 369
Brouwer (10.1016/j.isci.2022.104959_bib51) 2020; 369
Morita (10.1016/j.isci.2022.104959_bib28) 2011; 34
Crotty (10.1016/j.isci.2022.104959_bib8) 2015; 15
Sallusto (10.1016/j.isci.2022.104959_bib38) 1999; 401
Loyal (10.1016/j.isci.2022.104959_bib24) 2021; 374
Poon (10.1016/j.isci.2022.104959_bib35) 2021; 6
Kondo (10.1016/j.isci.2022.104959_bib20) 2007; 37
Le Bert (10.1016/j.isci.2022.104959_bib1) 2020; 584
Tan (10.1016/j.isci.2022.104959_bib44) 2021; 34
Lineburg (10.1016/j.isci.2022.104959_bib21) 2021; 54
Dan (10.1016/j.isci.2022.104959_bib9) 2021; 371
DuPage (10.1016/j.isci.2022.104959_bib10) 2016; 16
Muecksch (10.1016/j.isci.2022.104959_bib31) 2021; 54
Chen (10.1016/j.isci.2022.104959_bib7) 2020; 5
Juno (10.1016/j.isci.2022.104959_bib17) 2020; 26
Karim (10.1016/j.isci.2022.104959_bib18) 2021; 398
Long (10.1016/j.isci.2022.104959_bib23) 2021; 7
Rydyznski Moderbacher (10.1016/j.isci.2022.104959_bib27) 2020; 183
Ueno (10.1016/j.isci.2022.104959_bib46) 2015; 16
Sekine (10.1016/j.isci.2022.104959_bib40) 2020; 183
References_xml – volume: 2
  start-page: eaan5393
  year: 2017
  ident: bib50
  article-title: Recovery from the Middle East respiratory syndrome is associated with antibody and T cell responses
  publication-title: Sci. Immunol.
– volume: 369
  start-page: 643
  year: 2020
  end-page: 650
  ident: bib51
  article-title: Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
  publication-title: Science
– volume: 9
  start-page: e57063
  year: 2020
  ident: bib19
  article-title: Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs
  publication-title: Elife
– volume: 26
  start-page: 845
  year: 2020
  end-page: 848
  ident: bib22
  article-title: Antibody responses to SARS-CoV-2 in patients with COVID-19
  publication-title: Nat. Med.
– volume: 584
  start-page: 437
  year: 2020
  end-page: 442
  ident: bib36
  article-title: Convergent antibody responses to SARS-CoV-2 in convalescent individuals
  publication-title: Nature
– volume: 12
  start-page: 467
  year: 2011
  end-page: 471
  ident: bib33
  article-title: Origins of CD4+ effector and central memory T cells
  publication-title: Nat. Immunol.
– volume: 15
  start-page: 185
  year: 2015
  end-page: 189
  ident: bib8
  article-title: A brief history of T cell help to B cells
  publication-title: Nat. Rev. Immunol.
– volume: 183
  start-page: 1024
  year: 2020
  end-page: 1042.e21
  ident: bib34
  article-title: Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
  publication-title: Cell
– volume: 587
  start-page: 270
  year: 2020
  end-page: 274
  ident: bib5
  article-title: SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
  publication-title: Nature
– volume: 26
  start-page: 1428
  year: 2020
  end-page: 1434
  ident: bib17
  article-title: Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
  publication-title: Nat. Med.
– volume: 17
  start-page: e1009761
  year: 2021
  ident: bib4
  article-title: SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence
  publication-title: PLoS Pathog.
– volume: 51
  start-page: 1535
  year: 2021
  end-page: 1538
  ident: bib39
  article-title: Enrichment of CCR6+CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19
  publication-title: Eur. J. Immunol.
– volume: 5
  start-page: 180
  year: 2020
  ident: bib7
  article-title: Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
  publication-title: Signal Transduct. Target. Ther.
– volume: 12
  start-page: 1162
  year: 2021
  ident: bib49
  article-title: Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
  publication-title: Nat. Commun.
– volume: 16
  start-page: 149
  year: 2016
  end-page: 163
  ident: bib10
  article-title: Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
  publication-title: Nat. Rev. Immunol.
– volume: 29
  start-page: 1124
  year: 2021
  end-page: 1136.e11
  ident: bib30
  article-title: SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
  publication-title: Cell Host Microbe
– volume: 371
  start-page: eabf4063
  year: 2021
  ident: bib9
  article-title: Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
  publication-title: Science
– volume: 204
  start-page: 2803
  year: 2007
  end-page: 2812
  ident: bib15
  article-title: Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
  publication-title: J. Exp. Med.
– volume: 184
  start-page: 861
  year: 2021
  end-page: 880
  ident: bib41
  article-title: Adaptive immunity to SARS-CoV-2 and COVID-19
  publication-title: Cell
– volume: 28
  start-page: 847
  year: 2008
  end-page: 858
  ident: bib42
  article-title: Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities
  publication-title: Immunity
– volume: 194
  start-page: 1711
  year: 2001
  end-page: 1719
  ident: bib13
  article-title: Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4+ T cells
  publication-title: J. Exp. Med.
– volume: 401
  start-page: 708
  year: 1999
  end-page: 712
  ident: bib38
  article-title: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
  publication-title: Nature
– volume: 183
  start-page: 996
  year: 2020
  end-page: 1012.e19
  ident: bib27
  article-title: Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
  publication-title: Cell
– volume: 54
  start-page: 1055
  year: 2021
  end-page: 1065.e5
  ident: bib21
  article-title: CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses
  publication-title: Immunity
– volume: 595
  start-page: 426
  year: 2021
  end-page: 431
  ident: bib47
  article-title: Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
  publication-title: Nature
– volume: 184
  start-page: 476
  year: 2021
  end-page: 488.e11
  ident: bib12
  article-title: COVID-19-neutralizing antibodies predict disease severity and survival
  publication-title: Cell
– volume: 181
  start-page: 1489
  year: 2020
  end-page: 1501.e15
  ident: bib14
  article-title: Targets of T Cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
  publication-title: Cell
– volume: 183
  start-page: 1340
  year: 2020
  end-page: 1353.e16
  ident: bib26
  article-title: Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
  publication-title: Cell
– year: 2021
  ident: bib32
  article-title: Third BNT162b2 vaccination neutralization of SARS-CoV-2 Omicron infection
  publication-title: medRxiv
– volume: 11
  start-page: 3434
  year: 2020
  ident: bib3
  article-title: Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
  publication-title: Nat. Commun.
– volume: 183
  start-page: 158
  year: 2020
  end-page: 168.e14
  ident: bib40
  article-title: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
  publication-title: Cell
– volume: 184
  start-page: 169
  year: 2021
  end-page: 183.e17
  ident: bib37
  article-title: Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
  publication-title: Cell
– volume: 12
  start-page: 4043
  year: 2021
  ident: bib16
  article-title: SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells
  publication-title: Nat. Commun.
– volume: 186
  start-page: 7264
  year: 2011
  end-page: 7268
  ident: bib45
  article-title: Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study
  publication-title: J. Immunol.
– volume: 218
  year: 2021
  ident: bib2
  article-title: Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
  publication-title: J. Exp. Med.
– volume: 180
  start-page: 214
  year: 2008
  end-page: 221
  ident: bib43
  article-title: Human T cells that are able to produce IL-17 express the chemokine receptor CCR6
  publication-title: J. Immunol.
– volume: 37
  start-page: 54
  year: 2007
  end-page: 65
  ident: bib20
  article-title: Functional expression of chemokine receptor CCR6 on human effector memory CD8+ T cells
  publication-title: Eur. J. Immunol.
– volume: 7
  start-page: 18
  year: 2021
  ident: bib23
  article-title: Immune memory in convalescent patients with asymptomatic or mild COVID-19
  publication-title: Cell Discov.
– volume: 54
  start-page: 1853
  year: 2021
  end-page: 1868.e7
  ident: bib31
  article-title: Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
  publication-title: Immunity
– volume: 398
  start-page: 2126
  year: 2021
  end-page: 2128
  ident: bib18
  article-title: Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic
  publication-title: Lancet
– volume: 54
  start-page: 1841
  year: 2021
  end-page: 1852.e4
  ident: bib29
  article-title: Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
  publication-title: Immunity
– year: 2021
  ident: bib6
  article-title: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection
  publication-title: medRxiv
– volume: 374
  start-page: eabh1823
  year: 2021
  ident: bib24
  article-title: Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
  publication-title: Science
– volume: 584
  start-page: 457
  year: 2020
  end-page: 462
  ident: bib1
  article-title: SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
  publication-title: Nature
– volume: 58
  start-page: 88
  year: 2005
  end-page: 94
  ident: bib52
  article-title: Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies
  publication-title: Jpn J Infect Dis.
– volume: 591
  start-page: 639
  year: 2021
  end-page: 644
  ident: bib11
  article-title: Evolution of antibody immunity to SARS-CoV-2
  publication-title: Nature
– volume: 9
  start-page: 1
  year: 1998
  end-page: 11
  ident: bib48
  article-title: Chemokines and T Lymphocytes more than an attraction
  publication-title: Immunity
– volume: 369
  start-page: eabc8511
  year: 2020
  ident: bib25
  article-title: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
  publication-title: Science
– volume: 34
  start-page: 108728
  year: 2021
  ident: bib44
  article-title: Early induction of functional SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients
  publication-title: Cell Rep.
– volume: 16
  start-page: 142
  year: 2015
  end-page: 152
  ident: bib46
  article-title: Pathophysiology of T follicular helper cells in humans and mice
  publication-title: Nat. Immunol.
– volume: 34
  start-page: 108
  year: 2011
  end-page: 121
  ident: bib28
  article-title: Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
  publication-title: Immunity
– volume: 6
  start-page: eabl9105
  year: 2021
  ident: bib35
  article-title: SARS-CoV-2 infection generates tissue-localized immunological memory in humans
  publication-title: Sci. Immunol.
– volume: 218
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib2
  article-title: Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20202617
– volume: 369
  start-page: eabc8511
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib25
  article-title: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
  publication-title: Science
  doi: 10.1126/science.abc8511
– volume: 54
  start-page: 1853
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib31
  article-title: Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
  publication-title: Immunity
  doi: 10.1016/j.immuni.2021.07.008
– volume: 183
  start-page: 1340
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib26
  article-title: Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2020.10.001
– volume: 183
  start-page: 158
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib40
  article-title: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2020.08.017
– volume: 17
  start-page: e1009761
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib4
  article-title: SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1009761
– volume: 16
  start-page: 149
  year: 2016
  ident: 10.1016/j.isci.2022.104959_bib10
  article-title: Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2015.18
– volume: 184
  start-page: 476
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib12
  article-title: COVID-19-neutralizing antibodies predict disease severity and survival
  publication-title: Cell
  doi: 10.1016/j.cell.2020.12.015
– volume: 34
  start-page: 108
  year: 2011
  ident: 10.1016/j.isci.2022.104959_bib28
  article-title: Human blood CXCR5+CD4+ T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.12.012
– volume: 7
  start-page: 18
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib23
  article-title: Immune memory in convalescent patients with asymptomatic or mild COVID-19
  publication-title: Cell Discov.
  doi: 10.1038/s41421-021-00250-9
– volume: 28
  start-page: 847
  year: 2008
  ident: 10.1016/j.isci.2022.104959_bib42
  article-title: Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.04.018
– volume: 374
  start-page: eabh1823
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib24
  article-title: Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
  publication-title: Science
  doi: 10.1126/science.abh1823
– volume: 11
  start-page: 3434
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib3
  article-title: Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17292-4
– volume: 29
  start-page: 1124
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib30
  article-title: SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.06.006
– volume: 12
  start-page: 1162
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib49
  article-title: Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21444-5
– volume: 6
  start-page: eabl9105
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib35
  article-title: SARS-CoV-2 infection generates tissue-localized immunological memory in humans
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.abl9105
– volume: 12
  start-page: 467
  year: 2011
  ident: 10.1016/j.isci.2022.104959_bib33
  article-title: Origins of CD4+ effector and central memory T cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2038
– volume: 5
  start-page: 180
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib7
  article-title: Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
  publication-title: Signal Transduct. Target. Ther.
  doi: 10.1038/s41392-020-00301-9
– volume: 37
  start-page: 54
  year: 2007
  ident: 10.1016/j.isci.2022.104959_bib20
  article-title: Functional expression of chemokine receptor CCR6 on human effector memory CD8+ T cells
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200636251
– volume: 51
  start-page: 1535
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib39
  article-title: Enrichment of CCR6+CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.202049046
– volume: 54
  start-page: 1055
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib21
  article-title: CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses
  publication-title: Immunity
  doi: 10.1016/j.immuni.2021.04.006
– volume: 183
  start-page: 1024
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib34
  article-title: Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.037
– volume: 34
  start-page: 108728
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib44
  article-title: Early induction of functional SARS-CoV-2 specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.108728
– volume: 9
  start-page: 1
  year: 1998
  ident: 10.1016/j.isci.2022.104959_bib48
  article-title: Chemokines and T Lymphocytes more than an attraction
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80583-X
– volume: 58
  start-page: 88
  year: 2005
  ident: 10.1016/j.isci.2022.104959_bib52
  article-title: Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies
  publication-title: Jpn J Infect Dis.
  doi: 10.7883/yoken.JJID.2005.88
– volume: 587
  start-page: 270
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib5
  article-title: SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
  publication-title: Nature
  doi: 10.1038/s41586-020-2598-9
– volume: 369
  start-page: 643
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib51
  article-title: Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
  publication-title: Science
  doi: 10.1126/science.abc5902
– volume: 584
  start-page: 437
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib36
  article-title: Convergent antibody responses to SARS-CoV-2 in convalescent individuals
  publication-title: Nature
  doi: 10.1038/s41586-020-2456-9
– volume: 16
  start-page: 142
  year: 2015
  ident: 10.1016/j.isci.2022.104959_bib46
  article-title: Pathophysiology of T follicular helper cells in humans and mice
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3054
– volume: 181
  start-page: 1489
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib14
  article-title: Targets of T Cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
  publication-title: Cell
  doi: 10.1016/j.cell.2020.05.015
– volume: 398
  start-page: 2126
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib18
  article-title: Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)02758-6
– volume: 9
  start-page: e57063
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib19
  article-title: Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs
  publication-title: Elife
  doi: 10.7554/eLife.57063
– volume: 584
  start-page: 457
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib1
  article-title: SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
  publication-title: Nature
  doi: 10.1038/s41586-020-2550-z
– volume: 591
  start-page: 639
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib11
  article-title: Evolution of antibody immunity to SARS-CoV-2
  publication-title: Nature
  doi: 10.1038/s41586-021-03207-w
– volume: 401
  start-page: 708
  year: 1999
  ident: 10.1016/j.isci.2022.104959_bib38
  article-title: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
  publication-title: Nature
  doi: 10.1038/44385
– year: 2021
  ident: 10.1016/j.isci.2022.104959_bib6
  article-title: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection
  publication-title: medRxiv
– volume: 371
  start-page: eabf4063
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib9
  article-title: Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
  publication-title: Science
  doi: 10.1126/science.abf4063
– volume: 54
  start-page: 1841
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib29
  article-title: Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
  publication-title: Immunity
  doi: 10.1016/j.immuni.2021.06.015
– volume: 26
  start-page: 1428
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib17
  article-title: Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-0995-0
– volume: 184
  start-page: 861
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib41
  article-title: Adaptive immunity to SARS-CoV-2 and COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2021.01.007
– volume: 595
  start-page: 426
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib47
  article-title: Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
  publication-title: Nature
  doi: 10.1038/s41586-021-03696-9
– volume: 2
  start-page: eaan5393
  year: 2017
  ident: 10.1016/j.isci.2022.104959_bib50
  article-title: Recovery from the Middle East respiratory syndrome is associated with antibody and T cell responses
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.aan5393
– volume: 12
  start-page: 4043
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib16
  article-title: SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-24377-1
– volume: 186
  start-page: 7264
  year: 2011
  ident: 10.1016/j.isci.2022.104959_bib45
  article-title: Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0903490
– volume: 15
  start-page: 185
  year: 2015
  ident: 10.1016/j.isci.2022.104959_bib8
  article-title: A brief history of T cell help to B cells
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3803
– volume: 26
  start-page: 845
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib22
  article-title: Antibody responses to SARS-CoV-2 in patients with COVID-19
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-0897-1
– volume: 194
  start-page: 1711
  year: 2001
  ident: 10.1016/j.isci.2022.104959_bib13
  article-title: Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4+ T cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.194.12.1711
– volume: 184
  start-page: 169
  year: 2021
  ident: 10.1016/j.isci.2022.104959_bib37
  article-title: Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
  publication-title: Cell
  doi: 10.1016/j.cell.2020.11.029
– volume: 204
  start-page: 2803
  year: 2007
  ident: 10.1016/j.isci.2022.104959_bib15
  article-title: Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20071397
– year: 2021
  ident: 10.1016/j.isci.2022.104959_bib32
  article-title: Third BNT162b2 vaccination neutralization of SARS-CoV-2 Omicron infection
  publication-title: medRxiv
– volume: 183
  start-page: 996
  year: 2020
  ident: 10.1016/j.isci.2022.104959_bib27
  article-title: Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.038
– volume: 180
  start-page: 214
  year: 2008
  ident: 10.1016/j.isci.2022.104959_bib43
  article-title: Human T cells that are able to produce IL-17 express the chemokine receptor CCR6
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.1.214
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Snippet Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition,...
Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition,...
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SubjectTerms Biological sciences
Health sciences
Immunology
Medicine
Virology
Title SARS-CoV-2-specific CD4+ T cell longevity correlates with Th17-like phenotype
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