Role of pattern recognition receptors and interferon-beta in protecting bat cell lines from encephalomyocarditis virus and Japanese encephalitis virus infection

• Published in: Biochemical and biophysical research communications Vol. 527; no. 1; pp. 1 - 7
• Main Authors: Tarigan, Ronald, Shimoda, Hiroshi, Doysabas, Karla Cristine C., Ken, Maeda, Iida, Atsuo, Hondo, Eiichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.06.2020
• Subjects: Animals; antisense RNA; Bat; Bird Diseases - immunology; Bird Diseases - virology; Cardiovirus A; Cardiovirus Infections - immunology; Cardiovirus Infections - veterinary; Cell Line; cell lines; Chiroptera - immunology; Chiroptera - virology; EMCV; Encephalitis Virus, Japanese - immunology; Encephalitis, Japanese - immunology; Encephalitis, Japanese - veterinary; Encephalomyocarditis virus - immunology; epithelial cells; Humans; IFN-β; Immunity, Innate; innate immunity; interferon-beta; Interferon-beta - immunology; Japanese encephalitis virus; JEV; kidneys; Mesocricetus auratus; Miniopterus fuliginosus; oligonucleotides; PRRs; Pteropus; Receptors, Pattern Recognition - immunology; Rhinolophus ferrumequinum; Rousettus; virus replication; viruses; JEV; IFN-β; EMCV; Bat; PRRs

Bats are potential natural hosts of Encephalomyocarditis virus (EMCV) and Japanese encephalitis virus (JEV). Bats appear to have some unique features in their innate immune system that inhibit viral replication causing limited clinical symptoms, and thus, contributing to the virus spill over to huma...