Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal

B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 108; no. 14; pp. 5560 - 5565
Main Authors Cheng, Julong, Torkamani, Ali, Grover, Rajesh K, Jones, Teresa M, Ruiz, Diana I, Schork, Nicholas J, Quigley, Michael M, Hall, F. Wesley, Salomon, Daniel R, Lerner, Richard A
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 05.04.2011
National Acad Sciences
Subjects
allografting
Amino Acid Sequence
Antibodies
Antibodies - genetics
Antibodies - immunology
antibody libraries
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Base Sequence
Beta cells
Biological Sciences
Biopsies
Blood
Cell Movement - immunology
Cells
Chronic infection
Clone Cells - immunology
clones
Cloning
Complementarity Determining Regions - genetics
complementarity-determining region 3
Gene Expression Regulation - immunology
Genes
Genes, Immunoglobulin - immunology
Germ cells
Germinal centers
Graft rejection
Graft Rejection - immunology
Human subjects
Humans
immunoglobulin genes
Immunoglobulins
In Situ Hybridization
Kidney
Kidney - cytology
Kidney - immunology
Kidney Transplantation
Kidneys
Libraries
Lymphocytes
Lymphocytes B
Lymphoid tissue
Lymphoma
Malignancy
Molecular Sequence Data
patients
Peripheral blood
Recombination
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Transplants & implants
Online AccessGet full text

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Abstract B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy.
AbstractList B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy.
B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy.
B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy. [PUBLICATION ABSTRACT]
B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy.B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy.
B cells and their immunoglobulin products participate in allograft rejection of t0ransplanted human kidneys in which an interesting feature is the presence of a germinal center like B-cell clusters in the allograft. We report here that the immunoglobulin repertoires of these infiltrating B cells are highly restricted and the B cells within a cluster are clonal. Antibody libraries made from the infiltrating B cells of individual patients unexpectedly revealed that each patient utilizes a particular set of dominant germ line genes as well as dominant complementarity determining region 3. Comparison of kidney and peripheral blood from the same patient showed that the immunoglobulin genes from both compartments had dominant clones, but they differed. The lymphocytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usually restricted to highly activated lymphocytes in germinal centers and lymphomas. An analogy can be made between the inescapable antigenic drive in chronic infection versus that in an allograft, both of which may lead to emergence of dominant B-cell clones and even lymphoid malignancy.
Author Jones, Teresa M
Grover, Rajesh K
Hall, F. Wesley
Quigley, Michael M
Cheng, Julong
Lerner, Richard A
Torkamani, Ali
Ruiz, Diana I
Schork, Nicholas J
Salomon, Daniel R
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Cites_doi 10.1111/j.1600-6143.2010.03087.x
10.4049/jimmunol.0803424
10.1038/ajg.2009.314
10.1111/j.1600-6143.2007.02013.x
10.1016/j.coi.2006.07.006
10.1126/science.274.5295.2092
10.1056/NEJMoa035588
10.1126/science.278.5336.298
10.1126/science.1067518
10.3324/haematol.2009.005983
10.1038/ki.2008.249
10.1016/j.smim.2007.12.004
10.1111/j.1600-6143.2004.00526.x
10.1126/science.1101148
10.1146/annurev.pathmechdis.3.121806.151508
10.1007/s00277-003-0677-2
10.1002/art.21062
10.1126/science.274.5295.2094
10.1111/j.1600-065X.1986.tb01483.x
10.1146/annurev.biochem.71.090501.150203
10.1126/science.2531466
10.1038/ni0901-793
10.1111/j.1600-6143.2008.02159.x
10.1097/MOT.0b013e3283342780
10.1172/JCI3234
10.1016/S0002-9440(10)61762-2
10.1172/JCI27476
10.2353/ajpath.2007.060554
10.1038/nri2807
10.1182/blood.V99.7.2459.h8002459_2459_2467
10.1016/j.bbapap.2009.06.030
10.1002/anie.200603381
10.1056/NEJMoa020009
10.1371/journal.pone.0006212
10.1016/0140-6736(93)91409-F
10.3109/10428199409049742
10.3892/ijo_00000618
10.1016/j.trre.2010.01.004
10.4049/jimmunol.0903589
10.1016/S0952-7915(02)00324-2
10.1002/art.11311
10.1038/348552a0
10.4049/jimmunol.169.4.1829
10.1172/JCI28993.
10.1182/blood-2005-09-3679
10.1073/pnas.0900563106
10.2215/CJN.05271008
10.1038/sj.ki.5002734
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Author contributions: J.C., R.K.G., T.M.J., D.R.S., and R.A.L. designed research; J.C., R.K.G., T.M.J., D.I.R. performed research; J.C., A.T., N.J.S., M.M.Q., F.W.H., D.R.S., and R.A.L. analyzed data; and J.C., D.R.S., and R.A.L. wrote the paper.
Contributed by Richard A. Lerner, January 25, 2011 (sent for review January 11, 2011)
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References e_1_3_3_16_2
e_1_3_3_18_2
e_1_3_3_39_2
e_1_3_3_12_2
e_1_3_3_37_2
e_1_3_3_14_2
e_1_3_3_35_2
e_1_3_3_33_2
e_1_3_3_10_2
e_1_3_3_31_2
e_1_3_3_40_2
e_1_3_3_5_2
e_1_3_3_7_2
e_1_3_3_9_2
e_1_3_3_27_2
e_1_3_3_29_2
e_1_3_3_23_2
e_1_3_3_25_2
e_1_3_3_46_2
e_1_3_3_1_2
e_1_3_3_44_2
e_1_3_3_3_2
e_1_3_3_21_2
e_1_3_3_42_2
Nzula S (e_1_3_3_48_2) 2003; 63
e_1_3_3_17_2
e_1_3_3_19_2
e_1_3_3_38_2
e_1_3_3_13_2
e_1_3_3_36_2
e_1_3_3_15_2
e_1_3_3_34_2
e_1_3_3_32_2
e_1_3_3_11_2
e_1_3_3_30_2
e_1_3_3_6_2
e_1_3_3_8_2
e_1_3_3_28_2
e_1_3_3_49_2
e_1_3_3_24_2
e_1_3_3_47_2
e_1_3_3_26_2
e_1_3_3_45_2
e_1_3_3_2_2
e_1_3_3_20_2
e_1_3_3_43_2
e_1_3_3_4_2
e_1_3_3_22_2
e_1_3_3_41_2
11869895 - Curr Opin Immunol. 2002 Apr;14(2):216-23
7873997 - Leuk Lymphoma. 1994 Nov;15(5-6):399-403
2531466 - Science. 1989 Dec 8;246(4935):1275-81
11549579 - Am J Pathol. 2001 Sep;159(3):861-73
17120282 - Angew Chem Int Ed Engl. 2006 Dec 11;45(48):8106-25
12810659 - Cancer Res. 2003 Jun 15;63(12):3275-80
12853585 - N Engl J Med. 2003 Jul 10;349(2):125-38
20149626 - Transplant Rev (Orlando). 2010 Apr;24(2):67-78
17255314 - Am J Pathol. 2007 Feb;170(2):457-68
19593431 - PLoS One. 2009;4(7):e6212
15319492 - Science. 2004 Sep 17;305(5691):1770-3
9323210 - Science. 1997 Oct 10;278(5336):298-301
18039144 - Annu Rev Pathol. 2008;3:189-220
16395399 - J Clin Invest. 2006 Jan;116(1):22-6
11526388 - Nat Immunol. 2001 Sep;2(9):793-5
18294345 - Am J Transplant. 2008 Apr;8(4):753-60
17949456 - Am J Transplant. 2007 Dec;7(12):2739-47
8102719 - Lancet. 1993 Sep 4;342(8871):575-7
2426181 - Immunol Rev. 1986 Jun;91:39-60
18547992 - Kidney Int. 2008 Sep;74(5):664-73
19251643 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4148-53
19532131 - Am J Gastroenterol. 2009 Aug;104(8):1932-7; quiz 1938
18243731 - Semin Immunol. 2008 Feb;20(1):26-42
12165506 - J Immunol. 2002 Aug 15;169(4):1829-36
8953042 - Science. 1996 Dec 20;274(5295):2092-4
20651744 - Nat Rev Immunol. 2010 Aug;10(8):543-53
14613282 - Arthritis Rheum. 2003 Nov;48(11):3187-201
20353479 - Am J Transplant. 2010 May;10(5):1117-25
19608670 - Haematologica. 2009 Aug;94(8):1109-23
16397126 - Blood. 2006 Apr 15;107(8):3034-44
16998590 - J Clin Invest. 2006 Oct;116(10):2622-32
16879953 - Curr Opin Immunol. 2006 Oct;18(5):576-9
12045092 - Annu Rev Biochem. 2002;71:101-32
15934082 - Arthritis Rheum. 2005 Jun;52(6):1773-84
19596089 - Biochim Biophys Acta. 2010 May;1804(5):1151-66
8953043 - Science. 1996 Dec 20;274(5295):2094-7
19339427 - Clin J Am Soc Nephrol. 2009 Apr;4(4):860-5
18094677 - Kidney Int. 2008 Mar;73(5):533-7
12845479 - Ann Hematol. 2003 Sep;82(9):535-45
12098702 - Science. 2002 Jul 5;297(5578):110-3
19898237 - Curr Opin Organ Transplant. 2010 Feb;15(1):16-20
2247164 - Nature. 1990 Dec 6;348(6301):552-4
20428756 - Int J Oncol. 2010 Jun;36(6):1331-40
9727062 - J Clin Invest. 1998 Sep 1;102(5):938-46
19234230 - J Immunol. 2009 Mar 1;182(5):3310-7
14668458 - N Engl J Med. 2003 Dec 11;349(24):2326-33
20525884 - J Immunol. 2010 Jul 1;185(1):717-28
15307835 - Am J Transplant. 2004 Sep;4(9):1475-89
11895780 - Blood. 2002 Apr 1;99(7):2459-67
References_xml – ident: e_1_3_3_2_2
  doi: 10.1111/j.1600-6143.2010.03087.x
– ident: e_1_3_3_49_2
  doi: 10.4049/jimmunol.0803424
– ident: e_1_3_3_45_2
  doi: 10.1038/ajg.2009.314
– ident: e_1_3_3_13_2
  doi: 10.1111/j.1600-6143.2007.02013.x
– ident: e_1_3_3_8_2
  doi: 10.1016/j.coi.2006.07.006
– ident: e_1_3_3_27_2
  doi: 10.1126/science.274.5295.2092
– ident: e_1_3_3_12_2
  doi: 10.1056/NEJMoa035588
– ident: e_1_3_3_25_2
  doi: 10.1126/science.278.5336.298
– ident: e_1_3_3_29_2
  doi: 10.1126/science.1067518
– ident: e_1_3_3_46_2
  doi: 10.3324/haematol.2009.005983
– ident: e_1_3_3_6_2
  doi: 10.1038/ki.2008.249
– ident: e_1_3_3_11_2
  doi: 10.1016/j.smim.2007.12.004
– ident: e_1_3_3_18_2
  doi: 10.1111/j.1600-6143.2004.00526.x
– ident: e_1_3_3_33_2
  doi: 10.1126/science.1101148
– ident: e_1_3_3_1_2
  doi: 10.1146/annurev.pathmechdis.3.121806.151508
– ident: e_1_3_3_37_2
  doi: 10.1007/s00277-003-0677-2
– ident: e_1_3_3_41_2
  doi: 10.1002/art.21062
– ident: e_1_3_3_26_2
  doi: 10.1126/science.274.5295.2094
– ident: e_1_3_3_32_2
  doi: 10.1111/j.1600-065X.1986.tb01483.x
– ident: e_1_3_3_22_2
  doi: 10.1146/annurev.biochem.71.090501.150203
– ident: e_1_3_3_15_2
  doi: 10.1126/science.2531466
– ident: e_1_3_3_38_2
  doi: 10.1038/ni0901-793
– ident: e_1_3_3_17_2
  doi: 10.1111/j.1600-6143.2008.02159.x
– ident: e_1_3_3_5_2
  doi: 10.1097/MOT.0b013e3283342780
– volume: 63
  start-page: 3275
  year: 2003
  ident: e_1_3_3_48_2
  article-title: Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas
  publication-title: Cancer Res
– ident: e_1_3_3_35_2
  doi: 10.1172/JCI3234
– ident: e_1_3_3_43_2
  doi: 10.1016/S0002-9440(10)61762-2
– ident: e_1_3_3_44_2
  doi: 10.1172/JCI27476
– ident: e_1_3_3_7_2
  doi: 10.2353/ajpath.2007.060554
– ident: e_1_3_3_23_2
  doi: 10.1038/nri2807
– ident: e_1_3_3_31_2
  doi: 10.1182/blood.V99.7.2459.h8002459_2459_2467
– ident: e_1_3_3_24_2
  doi: 10.1016/j.bbapap.2009.06.030
– ident: e_1_3_3_14_2
  doi: 10.1002/anie.200603381
– ident: e_1_3_3_20_2
  doi: 10.1056/NEJMoa020009
– ident: e_1_3_3_19_2
  doi: 10.1371/journal.pone.0006212
– ident: e_1_3_3_36_2
  doi: 10.1016/0140-6736(93)91409-F
– ident: e_1_3_3_28_2
  doi: 10.3109/10428199409049742
– ident: e_1_3_3_39_2
  doi: 10.3892/ijo_00000618
– ident: e_1_3_3_3_2
  doi: 10.1016/j.trre.2010.01.004
– ident: e_1_3_3_10_2
  doi: 10.4049/jimmunol.0903589
– ident: e_1_3_3_30_2
  doi: 10.1016/S0952-7915(02)00324-2
– ident: e_1_3_3_40_2
  doi: 10.1002/art.11311
– ident: e_1_3_3_16_2
  doi: 10.1038/348552a0
– ident: e_1_3_3_47_2
  doi: 10.4049/jimmunol.169.4.1829
– ident: e_1_3_3_42_2
  doi: 10.1172/JCI28993.
– ident: e_1_3_3_34_2
  doi: 10.1182/blood-2005-09-3679
– ident: e_1_3_3_4_2
  doi: 10.1073/pnas.0900563106
– ident: e_1_3_3_21_2
  doi: 10.2215/CJN.05271008
– ident: e_1_3_3_9_2
  doi: 10.1038/sj.ki.5002734
– reference: 12853585 - N Engl J Med. 2003 Jul 10;349(2):125-38
– reference: 15307835 - Am J Transplant. 2004 Sep;4(9):1475-89
– reference: 16998590 - J Clin Invest. 2006 Oct;116(10):2622-32
– reference: 14613282 - Arthritis Rheum. 2003 Nov;48(11):3187-201
– reference: 18294345 - Am J Transplant. 2008 Apr;8(4):753-60
– reference: 17120282 - Angew Chem Int Ed Engl. 2006 Dec 11;45(48):8106-25
– reference: 19608670 - Haematologica. 2009 Aug;94(8):1109-23
– reference: 18094677 - Kidney Int. 2008 Mar;73(5):533-7
– reference: 19898237 - Curr Opin Organ Transplant. 2010 Feb;15(1):16-20
– reference: 18243731 - Semin Immunol. 2008 Feb;20(1):26-42
– reference: 2426181 - Immunol Rev. 1986 Jun;91:39-60
– reference: 17255314 - Am J Pathol. 2007 Feb;170(2):457-68
– reference: 19596089 - Biochim Biophys Acta. 2010 May;1804(5):1151-66
– reference: 12045092 - Annu Rev Biochem. 2002;71:101-32
– reference: 20525884 - J Immunol. 2010 Jul 1;185(1):717-28
– reference: 16879953 - Curr Opin Immunol. 2006 Oct;18(5):576-9
– reference: 19339427 - Clin J Am Soc Nephrol. 2009 Apr;4(4):860-5
– reference: 19593431 - PLoS One. 2009;4(7):e6212
– reference: 18039144 - Annu Rev Pathol. 2008;3:189-220
– reference: 15934082 - Arthritis Rheum. 2005 Jun;52(6):1773-84
– reference: 9727062 - J Clin Invest. 1998 Sep 1;102(5):938-46
– reference: 19234230 - J Immunol. 2009 Mar 1;182(5):3310-7
– reference: 9323210 - Science. 1997 Oct 10;278(5336):298-301
– reference: 11869895 - Curr Opin Immunol. 2002 Apr;14(2):216-23
– reference: 12845479 - Ann Hematol. 2003 Sep;82(9):535-45
– reference: 12165506 - J Immunol. 2002 Aug 15;169(4):1829-36
– reference: 20651744 - Nat Rev Immunol. 2010 Aug;10(8):543-53
– reference: 7873997 - Leuk Lymphoma. 1994 Nov;15(5-6):399-403
– reference: 16397126 - Blood. 2006 Apr 15;107(8):3034-44
– reference: 18547992 - Kidney Int. 2008 Sep;74(5):664-73
– reference: 19251643 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4148-53
– reference: 20353479 - Am J Transplant. 2010 May;10(5):1117-25
– reference: 11549579 - Am J Pathol. 2001 Sep;159(3):861-73
– reference: 2247164 - Nature. 1990 Dec 6;348(6301):552-4
– reference: 2531466 - Science. 1989 Dec 8;246(4935):1275-81
– reference: 20428756 - Int J Oncol. 2010 Jun;36(6):1331-40
– reference: 11895780 - Blood. 2002 Apr 1;99(7):2459-67
– reference: 20149626 - Transplant Rev (Orlando). 2010 Apr;24(2):67-78
– reference: 11526388 - Nat Immunol. 2001 Sep;2(9):793-5
– reference: 16395399 - J Clin Invest. 2006 Jan;116(1):22-6
– reference: 19532131 - Am J Gastroenterol. 2009 Aug;104(8):1932-7; quiz 1938
– reference: 14668458 - N Engl J Med. 2003 Dec 11;349(24):2326-33
– reference: 8102719 - Lancet. 1993 Sep 4;342(8871):575-7
– reference: 17949456 - Am J Transplant. 2007 Dec;7(12):2739-47
– reference: 8953043 - Science. 1996 Dec 20;274(5295):2094-7
– reference: 8953042 - Science. 1996 Dec 20;274(5295):2092-4
– reference: 12098702 - Science. 2002 Jul 5;297(5578):110-3
– reference: 12810659 - Cancer Res. 2003 Jun 15;63(12):3275-80
– reference: 15319492 - Science. 2004 Sep 17;305(5691):1770-3
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Snippet B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a...
B cells and their immunoglobulin products participate in allograft rejection of t0ransplanted human kidneys in which an interesting feature is the presence of...
B cells and their immunoglobulin products participate in allograft rejection of transplanted human kidneys in which an interesting feature is the presence of a...
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StartPage 5560
SubjectTerms allografting
Amino Acid Sequence
Antibodies
Antibodies - genetics
Antibodies - immunology
antibody libraries
B lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - immunology
Base Sequence
Beta cells
Biological Sciences
Biopsies
Blood
Cell Movement - immunology
Cells
Chronic infection
Clone Cells - immunology
clones
Cloning
Complementarity Determining Regions - genetics
complementarity-determining region 3
Gene Expression Regulation - immunology
Genes
Genes, Immunoglobulin - immunology
Germ cells
Germinal centers
Graft rejection
Graft Rejection - immunology
Human subjects
Humans
immunoglobulin genes
Immunoglobulins
In Situ Hybridization
Kidney
Kidney - cytology
Kidney - immunology
Kidney Transplantation
Kidneys
Libraries
Lymphocytes
Lymphocytes B
Lymphoid tissue
Lymphoma
Malignancy
Molecular Sequence Data
patients
Peripheral blood
Recombination
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Transplants & implants
Title Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal
URI https://www.jstor.org/stable/41125365
http://www.pnas.org/content/108/14/5560.abstract
https://www.ncbi.nlm.nih.gov/pubmed/21415369
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https://pubmed.ncbi.nlm.nih.gov/PMC3078383
Volume 108
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