Pridopidine Reverses Phencyclidine-Induced Memory Impairment
Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D receptor (D R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor func...
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Published in | Frontiers in pharmacology Vol. 9; p. 338 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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10.04.2018
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Abstract | Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D
receptor (D
R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington's disease model mice and, in preliminarily reports, Huntington's disease patients. The present study examined the anti-amnesic potential of pridopidine. Thus, memory impairment was produced in mice by administration of phencyclidine (PCP, 10 mg/kg/day) for 10 days, followed by 14 days' treatment with pridopidine (6 mg/kg/day), or saline. Finally, novel object recognition performance was assessed in the animals. Mice receiving PCP and saline exhibited deficits in novel object recognition, as expected, while pridopidine treatment counteracted PCP-induced memory impairment. The effect of pridopidine was attenuated by co-administration of the sigma receptor antagonist, NE-100 (10 mg/kg). Our results suggest that pridopidine exerts anti-amnesic and potentially neuroprotective actions. These data provide new insights into the therapeutic potential of pridopidine as a pro-cognitive drug. |
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AbstractList | Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D
receptor (D
R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington's disease model mice and, in preliminarily reports, Huntington's disease patients. The present study examined the anti-amnesic potential of pridopidine. Thus, memory impairment was produced in mice by administration of phencyclidine (PCP, 10 mg/kg/day) for 10 days, followed by 14 days' treatment with pridopidine (6 mg/kg/day), or saline. Finally, novel object recognition performance was assessed in the animals. Mice receiving PCP and saline exhibited deficits in novel object recognition, as expected, while pridopidine treatment counteracted PCP-induced memory impairment. The effect of pridopidine was attenuated by co-administration of the sigma receptor antagonist, NE-100 (10 mg/kg). Our results suggest that pridopidine exerts anti-amnesic and potentially neuroprotective actions. These data provide new insights into the therapeutic potential of pridopidine as a pro-cognitive drug. Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D 2 receptor (D 2 R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington's disease model mice and, in preliminarily reports, Huntington's disease patients. The present study examined the anti-amnesic potential of pridopidine. Thus, memory impairment was produced in mice by administration of phencyclidine (PCP, 10 mg/kg/day) for 10 days, followed by 14 days' treatment with pridopidine (6 mg/kg/day), or saline. Finally, novel object recognition performance was assessed in the animals. Mice receiving PCP and saline exhibited deficits in novel object recognition, as expected, while pridopidine treatment counteracted PCP-induced memory impairment. The effect of pridopidine was attenuated by co-administration of the sigma receptor antagonist, NE-100 (10 mg/kg). Our results suggest that pridopidine exerts anti-amnesic and potentially neuroprotective actions. These data provide new insights into the therapeutic potential of pridopidine as a pro-cognitive drug. Pridopidine is in clinical trials for Huntington's diseasetreatment. Originally developedas a dopamine D2receptor (D2R) ligand, pridopidine displays about 100-fold higheraffinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows diseaseprogression and improves motor function in Huntington's disease model mice and,in preliminarily reports, Huntington's disease patients.The present study examinedthe anti-amnesic potential of pridopidine. Thus, memory impairment was produced inmice by administration of phencyclidine (PCP, 10 mg/kg/day) for 10 days, followedby 14 days' treatment with pridopidine (6 mg/kg/day), or saline. Finally, novel objectrecognition performance was assessed in the animals. Mice receiving PCP andsaline exhibited deficits in novel object recognition, as expected, while pridopidinetreatment counteracted PCP-induced memory impairment. The effect of pridopidine wasattenuated by co-administration of the sigma receptor antagonist, NE-100 (10 mg/kg).Our results suggest that pridopidine exerts anti-amnesic and potentially neuroprotectiveactions. These data provide new insights into the therapeutic potential of pridopidine asa pro-cognitive drug. Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R). Interestingly, pridopidine slows disease progression and improves motor function in Huntington's disease model mice and, in preliminarily reports, Huntington's disease patients. The present study examined the anti-amnesic potential of pridopidine. Thus, memory impairment was produced in mice by administration of phencyclidine (PCP, 10 mg/kg/day) for 10 days, followed by 14 days' treatment with pridopidine (6 mg/kg/day), or saline. Finally, novel object recognition performance was assessed in the animals. Mice receiving PCP and saline exhibited deficits in novel object recognition, as expected, while pridopidine treatment counteracted PCP-induced memory impairment. The effect of pridopidine was attenuated by co-administration of the sigma receptor antagonist, NE-100 (10 mg/kg). Our results suggest that pridopidine exerts anti-amnesic and potentially neuroprotective actions. These data provide new insights into the therapeutic potential of pridopidine as a pro-cognitive drug. |
Author | Sahlholm, Kristoffer Valle-León, Marta Ciruela, Francisco Fernández-Dueñas, Víctor |
AuthorAffiliation | 1 Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat , Barcelona , Spain 3 Institut de Neurociències, Universitat de Barcelona , Barcelona , Spain 2 Department of Neuroscience, Karolinska Institutet , Stockholm , Sweden |
AuthorAffiliation_xml | – name: 3 Institut de Neurociències, Universitat de Barcelona , Barcelona , Spain – name: 2 Department of Neuroscience, Karolinska Institutet , Stockholm , Sweden – name: 1 Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL-Universitat de Barcelona, L'Hospitalet de Llobregat , Barcelona , Spain |
Author_xml | – sequence: 1 givenname: Kristoffer surname: Sahlholm fullname: Sahlholm, Kristoffer organization: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden – sequence: 2 givenname: Marta surname: Valle-León fullname: Valle-León, Marta organization: Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain – sequence: 3 givenname: Víctor surname: Fernández-Dueñas fullname: Fernández-Dueñas, Víctor organization: Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain – sequence: 4 givenname: Francisco surname: Ciruela fullname: Ciruela, Francisco organization: Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain |
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CitedBy_id | crossref_primary_10_1016_j_nbd_2019_05_009 crossref_primary_10_3389_fneur_2021_658123 crossref_primary_10_1159_000524236 crossref_primary_10_1002_mdc3_13357 crossref_primary_10_1515_revneuro_2019_0085 crossref_primary_10_3389_fphar_2019_00528 crossref_primary_10_26508_lsa_202302199 crossref_primary_10_1093_schbul_sbab137 |
Cites_doi | 10.1016/S0968-0896(01)00011-6 10.1038/sj.npp.1301047 10.1002/(SICI)1097-4547(19980615)52:6<709::AID-JNR10>3.0.CO;2-U 10.1016/S1474-4422(11)70233-2 10.1016/j.pnpbp.2005.03.003 10.1038/mp.2012.3 10.1126/science.2660263 10.31887/DCNS.2006.8.1/acarlsson 10.1007/s00213-015-3997-8 10.1016/j.pnpbp.2004.05.004 10.1016/j.pneurobio.2017.03.008 10.1016/j.ejphar.2010.07.023 10.1016/j.nbd.2016.10.006 10.1124/jpet.106.102905 10.2174/1381612819666131216114240 10.1111/jcmm.12604 10.1021/jm901689v 10.1016/j.neuropsychologia.2010.01.023 10.1172/jci.insight.95665 10.1093/ilar.38.1.41 10.1093/hmg/ddw238 10.1016/j.pharmthera.2009.07.001 10.1002/mds.25362 |
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Keywords | phencyclidine sigma-1 receptor dopamine stabilizers cognition mice |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Luis F. Callado, University of the Basque Country (UPV/EHU), Spain Reviewed by: Dasiel Oscar Borroto-Escuela, Karolinska Institute (KI), Sweden; Karolina Pytka, Jagiellonian University, Poland This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology These authors have contributed equally to this work. |
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References | 29212949 - JCI Insight. 2017 Dec 7;2(23 ):null 27466197 - Hum Mol Genet. 2016 Sep 15;25(18):3975-3987 15913873 - Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):833-9 22349783 - Mol Psychiatry. 2013 Jan;18(1):12-4 16495935 - Neuropsychopharmacology. 2007 Mar;32(3):514-21 22071279 - Lancet Neurol. 2011 Dec;10(12):1049-57 19619582 - Pharmacol Ther. 2009 Nov;124(2):195-206 11528046 - ILAR J. 1997;38(1):41-48 2660263 - Science. 1989 Jun 16;244(4910):1360-2 11377189 - Bioorg Med Chem. 2001 May;9(5):1325-35 23450660 - Mov Disord. 2013 Sep;28(10):1407-15 20132832 - Neuropsychologia. 2010 Jul;48(8):2251-61 28377290 - Prog Neurobiol. 2017 Jun;153:18-45 26159455 - Psychopharmacology (Berl). 2015 Sep;232(18):3443-53 20155917 - J Med Chem. 2010 Mar 25;53(6):2510-20 24345269 - Curr Pharm Des. 2014;20(31):5104-14 26094900 - J Cell Mol Med. 2015 Nov;19(11):2540-8 16640125 - Dialogues Clin Neurosci. 2006;8(1):137-42 20667452 - Eur J Pharmacol. 2010 Oct 10;644(1-3):88-95 9669320 - J Neurosci Res. 1998 Jun 15;52(6):709-22 27818324 - Neurobiol Dis. 2017 Jan;97(Pt A):46-59 15276693 - Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):677-85 16648369 - J Pharmacol Exp Ther. 2006 Aug;318(2):810-8 de Yebenes (B4) 2011; 10 Berardi (B1) 2001; 9 Nilsson (B12) 2004; 28 Reilmann (B17) 2017; 32 Johnson (B9) 1998; 52 (B8) 2013; 28 Maurice (B10) 2009; 124 Hashimoto (B7) 2007; 32 Garcia-Miralles (B5) 2017; 2 Pettersson (B14) 2010; 53 Ryskamp (B19) 2017; 97 Ponten (B15) 2010; 644 Rajagopal (B16) 2014; 20 Sahlholm (B21) 2015; 232 Tyebji (B23) 2017; 153 Winters (B24) 2010; 48 Natesan (B11) 2006; 318 Sahlholm (B20) 2013; 18 Squitieri (B22) 2015; 19 Geva (B6) 2016; 25 Olney (B13) 1989; 244 Clark (B3) 1997; 38 Rung (B18) 2005; 29 Carlsson (B2) 2006; 8 |
References_xml | – volume: 9 start-page: 1325 year: 2001 ident: B1 article-title: A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(01)00011-6 contributor: fullname: Berardi – volume: 32 start-page: 514 year: 2007 ident: B7 article-title: Phencyclidine-Induced Cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301047 contributor: fullname: Hashimoto – volume: 52 start-page: 709 year: 1998 ident: B9 article-title: Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex publication-title: J. Neurosci. Res. doi: 10.1002/(SICI)1097-4547(19980615)52:6<709::AID-JNR10>3.0.CO;2-U contributor: fullname: Johnson – volume: 10 start-page: 1049 year: 2011 ident: B4 article-title: Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(11)70233-2 contributor: fullname: de Yebenes – volume: 29 start-page: 833 year: 2005 ident: B18 article-title: The dopaminergic stabilizers (−)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry. doi: 10.1016/j.pnpbp.2005.03.003 contributor: fullname: Rung – volume: 18 start-page: 12 year: 2013 ident: B20 article-title: The dopamine stabilizers ACR16 and (–)-OSU6162 display nanomolar affinities at the σ-1 receptor publication-title: Mol. Psychiatry doi: 10.1038/mp.2012.3 contributor: fullname: Sahlholm – volume: 244 start-page: 1360 year: 1989 ident: B13 article-title: Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs publication-title: Science doi: 10.1126/science.2660263 contributor: fullname: Olney – volume: 8 start-page: 137 year: 2006 ident: B2 article-title: A dopaminergic deficit hypothesis of schizophrenia: the path to discovery publication-title: Dialogues Clin. Neurosci. doi: 10.31887/DCNS.2006.8.1/acarlsson contributor: fullname: Carlsson – volume: 232 start-page: 3443 year: 2015 ident: B21 article-title: Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses publication-title: Psychopharmacology doi: 10.1007/s00213-015-3997-8 contributor: fullname: Sahlholm – volume: 28 start-page: 677 year: 2004 ident: B12 article-title: The dopaminergic stabiliser ACR16 counteracts the behavioural primitivization induced by the NMDA receptor antagonist MK-801 in mice: implications for cognition publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2004.05.004 contributor: fullname: Nilsson – volume: 153 start-page: 18 year: 2017 ident: B23 article-title: Synaptopathic mechanisms of neurodegeneration and dementia: insights from Huntington's disease publication-title: Prog. Neurobiology doi: 10.1016/j.pneurobio.2017.03.008 contributor: fullname: Tyebji – volume: 644 start-page: 88 year: 2010 ident: B15 article-title: In vivo pharmacology of the dopaminergic stabilizer pridopidine publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2010.07.023 contributor: fullname: Ponten – volume: 32 start-page: 489 year: 2017 ident: B17 article-title: Efficacy, safety, and tolerability of pridopidine in Huntington's disease (HD): results from the phase II dose-ranging study, pride-HD [abstract] publication-title: Mov. Disord. contributor: fullname: Reilmann – volume: 97 start-page: 46 year: 2017 ident: B19 article-title: The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2016.10.006 contributor: fullname: Ryskamp – volume: 318 start-page: 810 year: 2006 ident: B11 article-title: The dopamine stabilizers (S)-(-)-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-Methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo d2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor sid publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.106.102905 contributor: fullname: Natesan – volume: 20 start-page: 5104 year: 2014 ident: B16 article-title: The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia publication-title: Curr. Pharm. Des. doi: 10.2174/1381612819666131216114240 contributor: fullname: Rajagopal – volume: 19 start-page: 2540 year: 2015 ident: B22 article-title: Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.12604 contributor: fullname: Squitieri – volume: 53 start-page: 2510 year: 2010 ident: B14 article-title: Synthesis and evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D 2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16) publication-title: J. Med. Chem. doi: 10.1021/jm901689v contributor: fullname: Pettersson – volume: 48 start-page: 2251 year: 2010 ident: B24 article-title: Implications of animal object memory research for human amnesia publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2010.01.023 contributor: fullname: Winters – volume: 2 start-page: 95665 year: 2017 ident: B5 article-title: Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice publication-title: JCI Insight doi: 10.1172/jci.insight.95665 contributor: fullname: Garcia-Miralles – volume: 38 start-page: 41 year: 1997 ident: B3 article-title: Special Report: The 1996 guide for the care and use of laboratory animals publication-title: ILAR J. doi: 10.1093/ilar.38.1.41 contributor: fullname: Clark – volume: 25 start-page: 3975 year: 2016 ident: B6 article-title: Pridopidine activates neuroprotective pathways impaired in Huntington Disease publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddw238 contributor: fullname: Geva – volume: 124 start-page: 195 year: 2009 ident: B10 article-title: The pharmacology of sigma-1 receptors publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2009.07.001 contributor: fullname: Maurice – volume: 28 start-page: 1407 year: 2013 ident: B8 article-title: A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease publication-title: Mov. Disord. doi: 10.1002/mds.25362 |
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Snippet | Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D
receptor (D
R) ligand, pridopidine displays about... Pridopidine is in clinical trials for Huntington's diseasetreatment. Originally developedas a dopamine D2receptor (D2R) ligand, pridopidine displays about... Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D 2 receptor (D 2 R) ligand, pridopidine displays... Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about... |
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StartPage | 338 |
SubjectTerms | Assaigs clínics Central nervous system diseases Clinical trials cognition Dopamina Dopamine dopamine stabilizers Malalties del sistema nerviós central Malalties neurodegeneratives Medicin och hälsovetenskap mice Neurodegenerative Diseases Pharmacology phencyclidine sigma-1 receptor |
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Title | Pridopidine Reverses Phencyclidine-Induced Memory Impairment |
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