Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

• Published in: Cell Vol. 159; no. 7; pp. 1563 - 1577
• Main Authors: Rongvaux, Anthony, Jackson, Ruaidhrí, Harman, Christian C.D., Li, Tuo, West, A. Phillip, de Zoete, Marcel R., Wu, Youtong, Yordy, Brian, Lakhani, Saquib A., Kuan, Chia-Yi, Taniguchi, Tadatsugu, Shadel, Gerald S., Chen, Zhijian J., Iwasaki, Akiko, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.12.2014
• Subjects: Animals; Apoptosis; caspases; Caspases - metabolism; death; DNA, Mitochondrial - metabolism; immunity; inflammation; Inflammation - immunology; Inflammation - metabolism; Interferon Type I - immunology; Interferon Type I - metabolism; interferons; Mice; Mice, Knockout; mitochondria; mitochondrial DNA; mitochondrial membrane; Signal Transduction; Virus Diseases - immunology

The mechanism by which cells undergo death determines whether dying cells trigger inflammatory responses or remain immunologically silent. Mitochondria play a central role in the induction of cell death, as well as in immune signaling pathways. Here, we identify a mechanism by which mitochondria and...