Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

• Published in: Cell Vol. 185; no. 10; pp. 1709 - 1727.e18
• Main Authors: Li, Xiaofei, Wang, Hui, Yu, Xiang, Saha, Gundappa, Kalafati, Lydia, Ioannidis, Charalampos, Mitroulis, Ioannis, Netea, Mihai G., Chavakis, Triantafyllos, Hajishengallis, George
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.05.2022
• Subjects: Animals; Arthritis; bone marrow; bone marrow transplantation; comorbidities; disease severity; epigenetic rewiring; epigenetics; hematopoietic stem and progenitor cells; Hematopoietic Stem Cells; Immunity, Innate; inflammation; innate immunity; interleukin-1; Mice; Myelopoiesis; Periodontitis; phenotype; progeny; trained immunity; comorbidities; arthritis; inflammation; myelopoiesis; periodontitis; hematopoietic stem and progenitor cells; epigenetic rewiring; trained immunity; bone marrow transplantation

Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid progeny. We show here that maladaptive BM-mediated TII underlies inflammatory comorbidities, as exemplified by the periodontitis-...