Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B

• Published in: Cell Vol. 177; no. 6; pp. 1553 - 1565.e16
• Main Authors: Zhao, Xin, Zhang, Guigen, Liu, Sheng, Chen, Xiangpeng, Peng, Ruchao, Dai, Lianpan, Qu, Xiao, Li, Shihua, Song, Hao, Gao, Zhengrong, Yuan, Pengfei, Liu, Zhiheng, Li, Changyao, Shang, Zifang, Li, Yan, Zhang, Meifan, Qi, Jianxun, Wang, Han, Du, Ning, Wu, Yan, Bi, Yuhai, Gao, Shan, Shi, Yi, Yan, Jinghua, Zhang, Yong, Xie, Zhengde, Wei, Wensheng, Gao, George F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.05.2019
• Subjects: attachment; Capsid - metabolism; cryo-electron microscopy; cryo-EM; Cryoelectron Microscopy; echovirus; Enterovirus; Enterovirus B; Enterovirus B, Human - metabolism; Enterovirus B, Human - pathogenicity; Enterovirus Infections - metabolism; etiological agents; FcRn; Histocompatibility Antigens Class I - metabolism; Histocompatibility Antigens Class I - physiology; Histocompatibility Antigens Class I - ultrastructure; human neonatal Fc receptor; Humans; infectious diseases; Models, Molecular; Phylogeny; receptor; receptors; Receptors, Fc - metabolism; Receptors, Fc - physiology; Receptors, Fc - ultrastructure; uncoating; Virion; Virus Internalization; viruses; uncoating; receptor; enterovirus; attachment; FcRn; human neonatal Fc receptor; cryo-EM; echovirus

Enterovirus B (EV-B), a major proportion of the genus Enterovirus in the family Picornaviridae, is the causative agent of severe human infectious diseases. Although cellular receptors for coxsackievirus B in EV-B have been identified, receptors mediating virus entry, especially the uncoating process...