Nucleotide-binding oligomerization domain 1 (NOD1) regulates microglial activation in pseudorabies virus infection

• Published in: Veterinary research (Paris) Vol. 55; no. 1; p. 161
• Main Authors: Sun, Xiuxiu, Jin, Xinxin, Lin, Zhengdan, Liu, Xi, Yang, Junjie, Li, Li, Feng, Helong, Zhang, Wanpo, Gu, Changqin, Hu, Xueying, Liu, Xiaoli, Cheng, Guofu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.12.2024; BioMed Central; BMC
• Subjects: Animal experimentation; Animals; antigen presentation; Antigens; Aujeszky's disease; Cell Line; cell movement; central nervous system; cytokines; domain; Encephalitis; Encephalitis, Viral - veterinary; Encephalitis, Viral - virology; Female; genes; Health aspects; Herpesvirus 1, Suid - physiology; Inflammation; JNK; Life Sciences; macrophages; Mediation; Mice; Microglia; Microglia - metabolism; Microglia - virology; neuroglia; neuroinflammation; NF-κB; NOD1; Nod1 Signaling Adaptor Protein - genetics; Nod1 Signaling Adaptor Protein - metabolism; oligomerization; Oligomers; phagocytosis; plasmids; Pseudorabies - virology; pseudorabies virus; public health; secretion; Suid alphaherpesvirus 1; Swine; Swine Diseases - immunology; Swine Diseases - virology; transcriptomics; viral encephalitis; viruses; NF-κB; NOD1; neuroinflammation; JNK; pseudorabies virus; Microglia

The primary cause of viral encephalitis (VE) is invasion of the central nervous system (CNS) by the virus, which leads to neuroinflammation and poses a significant threat to global public health. Microglia, as CNS-resident macrophages, play a crucial role in neuroinflammation and are often identifie...