Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases

• Published in: Forensic science international Vol. 289; pp. 33 - 39
• Main Authors: Matsusue, Aya, Ikeda, Tomoya, Tani, Naoto, Waters, Brian, Hara, Kenji, Kashiwagi, Masayuki, Takayama, Mio, Ikematsu, Natsuki, Kubo, Shin-ichi, Ishikawa, Takaki
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2018; Elsevier Limited
• Subjects: alleles; Amphetamine; Amphetamines; Autopsies; Autopsy; Blood; Body fluids; Bone marrow; Central nervous system; Chromatography; CYP2D6 protein; Cytochrome; cytochrome P-450; Cytochrome P450; Cytochrome P450 2D6; Deoxyribonucleic acid; DNA; Dopamine; Drugs; Enzymes; Fluids; Forensic engineering; Forensic science; Forensic sciences; Gene frequency; Genetic testing; genotype; Genotype & phenotype; Genotypes; Heart; Mass spectrometry; Metabolism; Methamphetamine; methamphetamines; necropsy; pericardium; Phenotype; Phenotypes; Sample size; Scientific imaging; Urine; Phenotype; Amphetamine; Metabolism; Cytochrome P450 2D6; Methamphetamine

•CYP2D6 phenotypes were identified in methamphetamine (MA) abusers and controls.•MA and amphetamine (AMP) levels were measured in body fluids from MA abusers.•MA levels in urine and bone marrow were significantly higher in IM than in EM.•CYP2D6 phenotypes were not correlated with AMP concentrations...