MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical carcinoma cell lines

• Published in: Scientific reports Vol. 11; no. 1; pp. 14772 - 11
• Main Authors: Li, Su-Chen, Monazzam, Azita, Razmara, Masoud, Chu, Xia, Stålberg, Peter, Skogseid, Britt
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.07.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/67; Acid production; Cancer; Fatty acids; Fatty-acid synthase; Gene expression; Genetic transformation; Humanities and Social Sciences; Inactivation; Lipid metabolism; MicroRNAs; Mimicry; miRNA; multidisciplinary; Multiple endocrine neoplasia; Neuroendocrine tumors; Nucleic acids; Palmitic acid; Pancreas; Parathyroid; Pituitary; Science; Science (multidisciplinary); Surgery; Transcription; Transfection; Tumor cell lines; Tumorigenesis

Adrenocortical carcinoma is a rare aggressive disease commonly recurring regardless of radical surgery. Although data on genomic alterations in malignant tumors are accumulating, knowledge of molecular events of importance for initiation of adrenocortical transformation is scarce. In an attempt to r...