A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility

• Published in: Cell host & microbe Vol. 25; no. 1; pp. 153 - 165.e5
• Main Authors: Hou, Yingnan, Zhai, Yi, Feng, Li, Karimi, Hana Z., Rutter, Brian D., Zeng, Liping, Choi, Du Seok, Zhang, Bailong, Gu, Weifeng, Chen, Xuemei, Ye, Wenwu, Innes, Roger W., Zhai, Jixian, Ma, Wenbo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.01.2019
• Subjects: Arabidopsis; Arabidopsis - genetics; Arabidopsis - immunology; Arabidopsis - microbiology; Arabidopsis Proteins - genetics; biogenesis; disease susceptibility; Disease Susceptibility - microbiology; Gene Expression Regulation, Plant; Gene Silencing; genes; Genes, Reporter - genetics; host-induced gene silencing; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; immunity; microRNA; MicroRNAs - genetics; MicroRNAs - immunology; Nicotiana; pathogenesis; pathogens; Phosphoprotein Phosphatases - antagonists & inhibitors; Phosphoprotein Phosphatases - metabolism; Phytophthora; Phytophthora - metabolism; Phytophthora - pathogenicity; Plant Diseases - immunology; Plant Diseases - microbiology; plant immunity; Plant Immunity - genetics; Plant Immunity - immunology; Plant Leaves - immunology; Plant Leaves - microbiology; RNA interference; RNA Interference - immunology; RNA, Small Interfering - biosynthesis; RNA, Small Interfering - drug effects; RNA, Small Interfering - genetics; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; RNA-silencing suppressor; secondary small RNAs; Verticillium; Virulence; virulence factor; Virulence Factors - genetics; Virulence Factors - metabolism; pathogenesis; RNA interference; RNA-silencing suppressor; microRNA; host-induced gene silencing; secondary small RNAs; virulence factor; plant immunity

RNA silencing (RNAi) has a well-established role in anti-viral immunity in plants. The destructive eukaryotic pathogen Phytophthora encodes suppressors of RNAi (PSRs), which enhance plant susceptibility. However, the role of small RNAs in defense against eukaryotic pathogens is unclear. Here, we sho...