The Human brm Protein Is Cleaved during Apoptosis: The Role of Cathepsin G

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 98; no. 7; pp. 3814 - 3819
• Main Authors: Biggs, Joseph R., Yang, Jie, Gullberg, Urban, Muchardt, Christian, Yaniv, Moshe, Kraft, Andrew S.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.03.2001; National Acad Sciences; The National Academy of Sciences
• Subjects: Animals; Antibodies; Apoptosis; Apoptosis - physiology; Biological Sciences; Cathepsin G; Cathepsins - metabolism; Cell nucleus; Cells; Cellular biology; Clinical Medicine; COS Cells; Epithelial Cells - metabolism; Fibroblasts - metabolism; HeLa Cells; Hematologi; Hematology; Humans; Klinisk medicin; Mast cells; Medical and Health Sciences; Medicin och hälsovetenskap; Myeloid cells; Neutrophils; Peptides; Proteins; Serine Endopeptidases; Stem cells; Transcription Factors - metabolism; Ultraviolet Rays

The human brm (hbrm) protein (homologue of the Drosophila melanogaster brahma and Saccharomyces cervisiae SNF-2 proteins) is part of a polypeptide complex believed to regulate chromatin conformation. We have shown that the hbrm protein is cleaved in NB4 leukemic cells after induction of apoptosis by...