Pan-ebolavirus protective therapy by two multifunctional human antibodies

• Published in: Cell Vol. 184; no. 22; pp. 5593 - 5607.e18
• Main Authors: Gilchuk, Pavlo, Murin, Charles D., Cross, Robert W., Ilinykh, Philipp A., Huang, Kai, Kuzmina, Natalia, Borisevich, Viktoriya, Agans, Krystle N., Geisbert, Joan B., Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Bombardi, Robin G., Carnahan, Robert H., Bukreyev, Alexander, Geisbert, Thomas W., Ward, Andrew B., Crowe, James E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.10.2021
• Subjects: Amino Acid Sequence; Animals; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody therapeutics; Binding Sites; Cell Line; Cryoelectron Microscopy; Ebolavirus; Ebolavirus - immunology; Ebolavirus - ultrastructure; ebolavirus infection; epitope mapping; Epitopes - immunology; Female; glycoprotein; glycoproteins; Glycoproteins - chemistry; Glycoproteins - immunology; Hemorrhagic Fever, Ebola - immunology; Hemorrhagic Fever, Ebola - prevention & control; Hemorrhagic Fever, Ebola - virology; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Models, Molecular; neutralization; neutralizing antibodies; Primates; Receptors, Fc - metabolism; Recombinant Proteins - immunology; Sudan; therapeutics; viral antibodies; Viremia - immunology; Sudan; antibody therapeutics; Ebolavirus; neutralizing antibodies; glycoprotein; ebolavirus infection; viral antibodies; epitope mapping

Ebolaviruses cause a severe and often fatal illness with the potential for global spread. Monoclonal antibody-based treatments that have become available recently have a narrow therapeutic spectrum and are ineffective against ebolaviruses other than Ebola virus (EBOV), including medically important...