Pan-ebolavirus protective therapy by two multifunctional human antibodies - Gilchuk, Pavlo; Murin, Charles D.; Cross, Robert W.; Ilinykh, Philipp A.; Huang, Kai; Kuzmina, Natalia; Borisevich, Viktoriya; Agans, Krystle N.; Geisbert, Joan B.; Zost, Seth J.; Nargi, Rachel S.; Sutton, Rachel E.; et al. (Cell, 2021)
Keywords: Amino Acid Sequence; Animals; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody therapeutics; Binding Sites; Cell Line; Cryoelectron Microscopy; Ebolavirus; Ebolavirus - immunology; Ebolavirus - ultrastructure; ebolavirus infection; epitope mapping; Epitopes - immunology; Female; glycoprotein; glycoproteins; Glycoproteins - chemistry; Glycoproteins - immunology; Hemorrhagic Fever, Ebola - immunology; Hemorrhagic Fever, Ebola - prevention & control; Hemorrhagic Fever, Ebola - virology; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Models, Molecular; neutralization; neutralizing antibodies; Primates; Receptors, Fc - metabolism; Recombinant Proteins - immunology; Sudan; therapeutics; viral antibodies; Viremia - immunology; Sudan; antibody therapeutics; Ebolavirus; neutralizing antibodies; glycoprotein; ebolavirus infection; viral antibodies; epitope mapping