Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients

• Published in: Journal of lipid research Vol. 58; no. 3; pp. 586 - 599
• Main Authors: Contaifer, Daniel, Carl, Daniel E., Warncke, Urszula Osinska, Martin, Erika J., Mohammed, Bassem M., Van Tassell, Benjamin, Brophy, Donald F., Chalfant, Charles E., Wijesinghe, Dayanjan S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2017; Journal of Lipid Research; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: Adult; Biomarkers - blood; Blood Coagulation; Blood Coagulation Disorders - etiology; Blood Coagulation Disorders - metabolism; Blood Coagulation Disorders - pathology; Chromatography, High Pressure Liquid; Coagulation; coagulopathy; Female; Hemodialysis; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - pathology; Kidney Failure, Chronic - therapy; Lipid Metabolism; Lysophospholipids - metabolism; Male; Medicare; Middle Aged; monohexosyl ceramide; Patient-Oriented and Epidemiological Research; Peritoneal dialysis; Peritoneal Dialysis - adverse effects; Peritoneum; Renal Dialysis - adverse effects; renal disease; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - pathology; Renal Insufficiency, Chronic - therapy; Sphingolipids; Sphingolipids - metabolism; sphingomyelin; Sphingomyelins - metabolism; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Sphingosine 1-phosphate; Tissue factor; sphingomyelin; coagulopathy; monohexosyl ceramide; sphingosine 1-phosphate; sphingolipids; renal disease

Hemodialysis (HD) and peritoneal dialysis (PD) are the primary means of managing end stage renal disease (ESRD). However, these treatment modalities are associated with the onset of coagulation abnormalities. Effective management of coagulation risk among these patients requires the identification o...