Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia

• Published in: Schizophrenia research Vol. 118; no. 1-3; pp. 232 - 239
• Main Authors: Prasad, Konasale M., Bamne, Mikhil N., Shirts, Brian H., Goradia, Dhruman, Mannali, Vimal, Pancholi, Krishna M., Xue, Bai, McClain, Lora, Yolken, Robert H., Keshavan, Matcheri S., Nimgaonkar, Vishwajit L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2010; Elsevier
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Analysis of Variance; Biological and medical sciences; Cognition; Female; Genetic Variation; Genotype; Herpes Simplex Virus; Herpesvirus 1, Human - immunology; Histocompatibility Antigens Class I - genetics; Human viral diseases; Humans; Image Processing, Computer-Assisted - methods; Immune genes; Infectious diseases; Magnetic Resonance Imaging - methods; Male; Medical sciences; MICB; Morphometry; Multivariate Analysis; Neuroanatomy; Neuroimaging; Neuropsychological Tests; Prefrontal Cortex - pathology; Prefrontal Cortex - virology; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - genetics; Schizophrenia - pathology; Schizophrenia - virology; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Young Adult; Neuroimaging; Immune genes; Herpes Simplex Virus; Neuroanatomy; Schizophrenia; Cognition; Morphometry; MICB; Human; Genetic variability; Grey matter; Herpes; Exposure; Genetic determinism; Infection; Psychosis; Gene; First episode; Viral disease; Genetics

We previously reported reduced prefrontal cortex (PFC) grey matter volume among first episode, antipsychotic-naïve schizophrenia subjects (SZ) exposed to HSV1 but not among healthy subjects (HS) (Prasad et al., 2007). Independently, rs1051788, an exonic polymorphism of the MHC Class I polypeptide-re...