The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats

• Published in: Pharmacology, biochemistry and behavior Vol. 83; no. 1; pp. 28 - 34
• Main Authors: Thorsell, Annika, Slawecki, Craig J., El Khoury, Aram, Mathe, Aleksander A., Ehlers, Cindy L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2006; Elsevier Science
• Subjects: Adult and adolescent clinical studies; Animal models of depression; Animals; Anxiety; Anxiety - psychology; Behavior, Animal - physiology; Biological and medical sciences; Body Weight - physiology; Brain Chemistry - physiology; Caudate-putamen; Depression; Exploratory Behavior - physiology; Hypothalamus - metabolism; Hypothalamus - physiology; Male; Medical sciences; Mood disorders; Neostriatum - metabolism; Neostriatum - physiology; Neuropeptide Y - metabolism; Neuropeptides - metabolism; NPY; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Rats, Wistar; Social Isolation; Animal models of depression; Anxiety; Caudate-putamen; NPY; Mood disorder; Neuropeptide Y; Animal model; Rat; Rodentia; Central nervous system; Depression; Basal ganglion; Putamen; Encephalon; Vertebrata; Mammalia; Caudate nucleus; Social isolation; Animal; Behavior

NPY is one of the most abundantly expressed peptides within the CNS, and has been previously demonstrated to be altered in several animal models of depression, as well as to be differentially regulated by acute and repeated stress. The effect of social deprivation, through isolation housing, on brai...