SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses

• Published in: Cell Vol. 185; no. 5; pp. 872 - 880.e3
• Main Authors: Walls, Alexandra C., Sprouse, Kaitlin R., Bowen, John E., Joshi, Anshu, Franko, Nicholas, Navarro, Mary Jane, Stewart, Cameron, Cameroni, Elisabetta, McCallum, Matthew, Goecker, Erin A., Degli-Angeli, Emily J., Logue, Jenni, Greninger, Alex, Corti, Davide, Chu, Helen Y., Veesler, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.03.2022
• Subjects: antibodies; antigens; breakthrough infection; COVID-19; COVID-19 infection; Delta variant; durability; neutralization; pandemic; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; vaccine; vaccines; COVID-19; SARS-CoV-2; vaccine; neutralization; breakthrough infection; Delta variant; antibodies

Although infections among vaccinated individuals lead to milder COVID-19 symptoms relative to those in unvaccinated subjects, the specificity and durability of antibody responses elicited by breakthrough cases remain unknown. Here, we demonstrate that breakthrough infections induce serum-binding and...