Diabetes mellitus, vitamin D & osteoporosis: Insights

• Published in: Indian journal of medical research (New Delhi, India : 1994) Vol. 150; no. 5; pp. 425 - 428
• Main Authors: Goswami, Ravinder, Nair, Abilash
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.11.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow
• Subjects: Aged; Bone and Bones - metabolism; Bone and Bones - pathology; Collagen; Collagen Type I - genetics; Denosumab; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diet therapy; Energy Metabolism - genetics; Fractures; Humans; Insulin resistance; Metabolism; Metropolitan areas; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Osteoporosis; Osteoporosis - drug therapy; Osteoporosis - etiology; Osteoporosis - genetics; Osteoporosis - metabolism; Population; Receptors, Calcitriol - genetics; Rural areas; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use; Type 2 diabetes; Urban areas; Vitamin D; Vitamin D - genetics; Vitamin D Deficiency - drug therapy; Vitamin D Deficiency - etiology; Vitamin D Deficiency - genetics; Vitamin D Deficiency - metabolism; Vitamin deficiency; Vitamins; India
• ISSN: 0971-5916
• DOI: 10.4103/ijmr.IJMR_1920_19

The worsening of glycaemic control in diabetic patients during winter was also attributed to lowering of vitamin D levels during those months. [...]recently, these notions were driving clinicians to consider routine supplementation of vitamin D to patients with diabetes mellitus. [...]Wallace et al[26], showed absence of any effect of vitamin D supplementation on insulin resistance, beta cell dysfunction and glycaemic control in diabetic patients. [...]it seems vitamin D has no major-independent role in glycaemic control among patients with diabetes. Reciprocally, the action of insulin on osteoblastic receptors activates osteoclastic activity and increased undercarboxylated OC, resulting in a feed forward loop[30]. [...]the area of bone health in DM requires in-depth research in multiple areas such as alteration in bone quality, methods to investigate perturbed bone microarchitecture, diagnostic criteria for osteoporosis and choice of anti-osteoporotic medicines for best bone health.