New Found Hope for Antibiotic Discovery: Lipid II Inhibitors

• Published in: Chemistry : a European journal Vol. 22; no. 36; pp. 12606 - 12616
• Main Authors: Ng, Vivian, Chan, Weng C.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 26.08.2016; Wiley Subscription Services, Inc
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibiotics; Antiinfectives and antibacterials; Bacteria; Bacteria - drug effects; Cell Wall - drug effects; Chemistry; Depsipeptides - chemistry; Depsipeptides - pharmacology; Inhibitors; Lead compounds; lipid II inhibitors; Lipids; macrocyclic peptides; mannopeptimycin; Summaries; teixobactin; Uridine Diphosphate N-Acetylmuramic Acid - analogs & derivatives; Uridine Diphosphate N-Acetylmuramic Acid - antagonists & inhibitors; Uridine Diphosphate N-Acetylmuramic Acid - chemistry; Walls; lipid II inhibitors; mannopeptimycin; teixobactin; macrocyclic peptides; antibiotics

Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacteria...