Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain

• Published in: The FASEB journal Vol. 24; no. 8; pp. 3036 - 3051
• Main Authors: Nguyen, AnhThu, Rauch, Tibor A, Pfeifer, Gerd P, Hu, Valerie W
• Format: Journal Article
• Language: English
• Published: United States The Federation of American Societies for Experimental Biology 01.08.2010
• Subjects: Brain Chemistry; Cell Line; Child; Child Development Disorders, Pervasive - genetics; DNA Methylation; Epigenesis, Genetic; Genetic Predisposition to Disease; Humans; Lymphocytes - cytology; Male; Nuclear Receptor Subfamily 1, Group F, Member 1 - deficiency; Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics

Autism is currently considered a multigene disorder with epigenetic influences. To investigate the contribution of DNA methylation to autism spectrum disorders, we have recently completed large-scale methylation profiling by CpG island microarray analysis of lymphoblastoid cell lines derived from mo...