DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma

• Published in: The EMBO journal Vol. 42; no. 7; pp. e111961 - n/a
• Main Authors: Taffoni, Clara, Marines, Johanna, Chamma, Hanane, Guha, Soumyabrata, Saccas, Mathilde, Bouzid, Amel, Valadao, Ana‐Luiza Chaves, Maghe, Clément, Jardine, Jane, Park, Mi Kyung, Polak, Katarzyna, De Martino, Mara, Vanpouille‐Box, Claire, Del Rio, Maguy, Gongora, Celine, Gavard, Julie, Bidère, Nicolas, Song, Min Sup, Pineau, Donovan, Hugnot, Jean‐Philippe, Kissa, Karima, Fontenille, Laura, Blanchet, Fabien P, Vila, Isabelle K, Laguette, Nadine
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.04.2023; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Adaptive immunology; Biochemistry, Molecular Biology; Brain cancer; Cancer; Carcinogenesis; Catalytic activity; cGAS; Chemokines; Cooperation; Damage detection; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA Damage; DNA Repair; DNA-Activated Protein Kinase - metabolism; DNA‐PK; EMBO03; EMBO19; EMBO37; Gene expression; Genomics; Genotoxicity; Glioblastoma; Glioblastoma - genetics; Glioblastoma cells; Humans; Immunity, Innate; Immunogenicity; Immunology; Inflammation; Interferon; Interferon regulatory factor 3; Kinases; Life Sciences; Macrophages; Neurobiology; Neurons and Cognition; Nucleotidyltransferases - metabolism; Signaling; Synergism; Tumor cells; tumor immunogenicity; Tumor Microenvironment; Tumorigenesis; Tumors; cGAS; tumor immunogenicity; inflammation; DNA‐PK; DNA-PK
• ISSN: 0261-4189; 1460-2075; 1460-2075
• DOI: 10.15252/embj.2022111961

Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP‐AMP (cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used glioblastoma cells that show undetectable cGAS levels to address if alternat...