L-carnitine alleviates sciatic nerve crush injury in rats：functional and electron microscopy assessments

• Published in: Neural regeneration research Vol. 9; no. 10; pp. 1020 - 1024
• Main Authors: Avsar, Ummü Zeynep, Avsar, Umit, Aydin, Ali, Yayla, Muhammed, Ozturkkaragoz, Berna, Un, Harun, Saritemur, Murat, Mercantepe, Tolga
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 15.05.2014; Medknow Publications & Media Pvt. Ltd; Department of Medical Education, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey%Department of Family Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey%Department of 0rthopedics and Traumatology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey%Department of Pharmacology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey%Department of Pharmacology, Faculty of Pharmacy, Agr?University, Agr?, Turkey%Department of Biochemistry, Faculty of Pharmacy, Agr?University, Agr?, Turkey%Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey%Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey; Medknow Publications & Media Pvt Ltd
• Subjects: Aneurysms; Care and treatment; Diabetes; Electron microscopy; Health aspects; Injuries; L-肉碱; Levocarnitine; Microscopy; Research and Report; Sciatic nerve; Variance analysis; 坐骨神经; 左旋肉碱; 电子显微镜; 神经保护作用; 神经损伤; 糖尿病大鼠; 评估; Istanbul Turkey; Turkey; neural regeneration; neuroprotection; electron microscopy; L-carnitine; myelin sheath; nerve regeneration; peripheral nerve injury; axon; crush injury; sciatic nerve
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.133163

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuro-protective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved signiifcantly. These ifndings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.