Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

• Published in: Blood Vol. 113; no. 16; pp. 3821 - 3830
• Main Authors: Nakayama, Masafumi, Akiba, Hisaya, Takeda, Kazuyoshi, Kojima, Yuko, Hashiguchi, Masaaki, Azuma, Miyuki, Yagita, Hideo, Okumura, Ko
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 16.04.2009; Americain Society of Hematology
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Animals; Antibodies - pharmacology; Antigen Presentation - drug effects; Antigen Presentation - immunology; Apoptosis - immunology; Biological and medical sciences; CD8 Antigens - immunology; Cell interactions; Cell Line; Dendritic Cells - immunology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Hepatitis A Virus Cellular Receptor 2; Immune Tolerance - drug effects; Immune Tolerance - physiology; Immunobiology; Macrophages, Peritoneal - immunology; Mice; Phagocytosis - immunology; Rats; Receptors, Virus - antagonists & inhibitors; Receptors, Virus - immunology; Antigen presentation; Vertebrata; Mammalia; Acquired immunity; Mouse; Antigen presenting cell; Cell death; Animal; Rodentia; Phagocytosis; TIM3 gene; Apoptosis

Phagocytes such as macrophages and dendritic cells (DCs) engulf apoptotic cells to maintain peripheral immune tolerance. However, the mechanism for the recognition of dying cells by phagocytes is not fully understood. Here, we demonstrate that T-cell immunoglobulin mucin-3 (Tim-3) recognizes apoptot...