Decreased default-mode network homogeneity in unaffected siblings of schizophrenia patients at rest

• Published in: Psychiatry research. Neuroimaging Vol. 224; no. 3; pp. 218 - 224
• Main Authors: Guo, Wenbin, Liu, Feng, Yao, Dapeng, Jiang, Jiajing, Su, Qinji, Zhang, Zhikun, Zhang, Jian, Yu, Liuyu, Zhai, Jinguo, Xiao, Changqing
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.12.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Brain Mapping - methods; Default mode network; Female; Humans; Independent component analysis; Magnetic Resonance Imaging; Male; Medical sciences; Nerve Net - physiopathology; Network homogeneity; Parietal Lobe - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Radiology; Schizophrenia; Schizophrenia - physiopathology; Siblings; Unaffected siblings; Young Adult; Schizophrenia; Default mode network; Network homogeneity; Unaffected siblings; Independent component analysis; Psychosis; Human; Rest; Central nervous system; Homogeneity; Sibling; Encephalon

The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaf...