Decreased default-mode network homogeneity in unaffected siblings of schizophrenia patients at rest
The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaf...
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| Published in | Psychiatry research. Neuroimaging Vol. 224; no. 3; pp. 218 - 224 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Shannon
Elsevier Ireland Ltd
30.12.2014
Elsevier |
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| Abstract | The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients׳ siblings may improve understanding of the nature of schizophrenia.
•Little is known about the alterations of the DMN NH in schizophrenia siblings.•Unaffected siblings have unique advantage independent of clinical and treatment issues.•NH was used to investigate the network homogeneity of the DMN in siblings.•We introduce an alterative perspective of examining the DMN NH in the siblings. |
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| AbstractList | The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients׳ siblings may improve understanding of the nature of schizophrenia.
•Little is known about the alterations of the DMN NH in schizophrenia siblings.•Unaffected siblings have unique advantage independent of clinical and treatment issues.•NH was used to investigate the network homogeneity of the DMN in siblings.•We introduce an alterative perspective of examining the DMN NH in the siblings. The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients׳ siblings may improve understanding of the nature of schizophrenia. The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients׳ siblings may improve understanding of the nature of schizophrenia.The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients׳ siblings may improve understanding of the nature of schizophrenia. The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients' siblings may improve understanding of the nature of schizophrenia. Abstract The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings have unique advantages as subjects of neuroimaging studies independent of the clinical and treatment issues that complicate studies of the patients themselves. In the present study, we investigated NH of the DMN in unaffected siblings of schizophrenia. Participants comprised 46 unaffected siblings of schizophrenia patients and 50 age-, sex-, and education-matched healthy controls who underwent resting state functional magnetic resonance imaging (fMRI). Automated NH and group independent component analysis (ICA) approaches were used to analyze the data. Compared with healthy controls, the unaffected siblings of schizophrenia patients showed decreased DMN homogeneity in the left precuneus. No significantly increased DMN homogeneity was found in the sibling group relative to the control group. Our results suggest that there is decreased NH of the DMN in unaffected siblings of schizophrenia patients and indicate that the alternative perspective of examining the DMN NH in patients׳ siblings may improve understanding of the nature of schizophrenia. |
| Author | Guo, Wenbin Xiao, Changqing Su, Qinji Zhai, Jinguo Yao, Dapeng Zhang, Jian Yu, Liuyu Liu, Feng Jiang, Jiajing Zhang, Zhikun |
| Author_xml | – sequence: 1 givenname: Wenbin surname: Guo fullname: Guo, Wenbin email: guowenbin76@163.com organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 2 givenname: Feng surname: Liu fullname: Liu, Feng organization: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China – sequence: 3 givenname: Dapeng surname: Yao fullname: Yao, Dapeng organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 4 givenname: Jiajing surname: Jiang fullname: Jiang, Jiajing organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 5 givenname: Qinji surname: Su fullname: Su, Qinji organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 6 givenname: Zhikun surname: Zhang fullname: Zhang, Zhikun organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 7 givenname: Jian surname: Zhang fullname: Zhang, Jian organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 8 givenname: Liuyu surname: Yu fullname: Yu, Liuyu organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China – sequence: 9 givenname: Jinguo surname: Zhai fullname: Zhai, Jinguo organization: School of Mental Health, Jining Medical University, Shandong, Jining 272067, China – sequence: 10 givenname: Changqing surname: Xiao fullname: Xiao, Changqing organization: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China |
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| Keywords | Schizophrenia Default mode network Network homogeneity Unaffected siblings Independent component analysis Psychosis Human Rest Central nervous system Homogeneity Sibling Encephalon |
| Language | English |
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| Snippet | The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia.... Abstract The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in... |
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| SubjectTerms | Adult Adult and adolescent clinical studies Biological and medical sciences Brain Mapping - methods Default mode network Female Humans Independent component analysis Magnetic Resonance Imaging Male Medical sciences Nerve Net - physiopathology Network homogeneity Parietal Lobe - physiopathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Radiology Schizophrenia Schizophrenia - physiopathology Siblings Unaffected siblings Young Adult |
| Title | Decreased default-mode network homogeneity in unaffected siblings of schizophrenia patients at rest |
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