Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

• Published in: Neural regeneration research Vol. 12; no. 7; pp. 1137 - 1144
• Main Authors: Singh, Shamsher, Jamwal, Sumit, Kumar, Puneet
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 01.07.2017; I.K. Gujral Punjab Technical University, Jalandhar, Punjab, India%Department of Pharmacology, I.S.F College of Pharmacy, Ferozepur Road, Moga, Punjab, India; Department of Pharmacology, I.S.F College of Pharmacy, Ferozepur Road, Moga, Punjab, India; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: 5-羟吲哚乙酸; 6-tetrahydropyridine; Quercetin; Piperine; Parkinson′s disease; excitotoxicity; oxido-nitrosative stress; neurotransmitters; neural regeneration; Acids; Animals; Bioavailability; Cytokines; Dopamine; Drug dosages; nerve regeneration; 1-methy-4-phenyl-1; Neurotoxicity; Oxidative stress; Parkinson's disease; Tumor necrosis factor-TNF; 保护电位; 多巴胺能神经元; 槲皮素; 白细胞介素-1β; 神经毒性; 肿瘤坏死因子-α; 胡椒碱; United States > US; Parkinson's disease; Piperine; neural regeneration; neurotransmitters; Quercetin; nerve regeneration; 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine; excitotoxicity; oxido-nitrosative stress; 2; 3; 6-tetrahydropyridine; 1-methy-4-phenyl-1

1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP）is a neurotoxin that selectively damages dopaminergic neurons in the substantia nigra pars compacta and induces Parkinson＇s like symptoms in rodents.Quercetin（QC）is a natural polyphenolic bioflavonoid with potent antioxidant and anti-inflammatory prop...