HSP90 inhibitors and cancer: Prospects for use in targeted therapies (Review)

• Published in: Oncology reports Vol. 49; no. 1; p. 1
• Main Authors: Li, Zi-Nan, Luo, Ying
• Format: Journal Article
• Language: English
• Published: Athens Spandidos Publications 01.01.2023; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Adenosine triphosphatase; Binding sites; Breast cancer; Cancer; Cancer therapies; Cell cycle; Chemotherapy; Cytoplasm; Drug resistance; Endoplasmic reticulum; Health aspects; Heat shock proteins; Immunotherapy; Kinases; Medical prognosis; Metabolism; Proteins; Review; Signal transduction

Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways and correcting misfolded proteins in cancer cells by interacting with oncogenic client proteins and co-chaperones. The inhibition of HSP90 chaperone machinery has been demonstrated as a potential approach with...