Disease-specific autoantibody production in the lungs and salivary glands of anti-synthetase syndrome

• Published in: FRONTIERS IN IMMUNOLOGY Vol. 15; p. 1265792
• Main Authors: Takeshita, Masaru, Suzuki, Katsuya, Nakazawa, Maho, Kamata, Hirofumi, Ishii, Makoto, Oyamada, Yoshitaka, Oshima, Hisaji, Usuda, Satoshi, Tsunoda, Kazuyuki, Takeuchi, Tsutomu
• Format: Journal Article Publication
• Language: English
• Published: Switzerland Frontiers Media SA 13.06.2024; Frontiers Media S.A
• Subjects: Adult; Aged; anti-aminoacyl-tRNA synthetase antibody; anti-Ro52 antibody; anti-synthetase syndrome; Antibodies, Antinuclear - immunology; Autoantibodies - immunology; autoantibody; Autoantigens - immunology; B-Lymphocytes - immunology; Bronchoalveolar Lavage Fluid - immunology; Female; Humans; idiopathic inflammatory myopathy; Immunologic diseases. Allergy; Immunology; Lung - immunology; Lung - pathology; Lung Diseases, Interstitial - immunology; Male; Middle Aged; Myositis - immunology; RC581-607; salivary gland; Salivary Glands - immunology; Salivary Glands - pathology; idiopathic inflammatory myopathy; salivary gland; anti-Ro52 antibody; anti-synthetase syndrome; autoantibody; anti-aminoacyl-tRNA synthetase antibody

Interstitial lung disease is a common complication of anti-synthetase syndrome (ASS), and lymphocytic infiltration is often observed in the lesion. We have recently reported that disease-specific autoantibodies are produced by infiltrating lymphocytes in some autoimmune diseases. Here, we investigat...