A Single Nucleotide Polymorphism in 3′-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation

• Published in: The Journal of biological chemistry Vol. 287; no. 30; pp. 25163 - 25172
• Main Authors: Sato, Kayo, Yoshimura, Atsutoshi, Kaneko, Takashi, Ukai, Takashi, Ozaki, Yukio, Nakamura, Hirotaka, Li, Xinyue, Matsumura, Hiroyoshi, Hara, Yoshitaka, Ogata, Yorimasa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2012; American Society for Biochemistry and Molecular Biology
• Subjects: 3' Untranslated Regions - genetics; Alleles; Asian Continental Ancestry Group; Cell Line; Female; Gene Regulation; Genetic Polymorphism; Humans; Innate Immunity; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Interleukin-8 - genetics; Interleukin-8 - metabolism; Japan; Leukocytes, Mononuclear - metabolism; Lipopeptides - pharmacology; Lipopolysaccharide (LPS); Lipopolysaccharides - pharmacology; Male; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Periodontal Disease; Periodontitis - genetics; Periodontitis - metabolism; Polymorphism, Single Nucleotide; Protein Biosynthesis; Toll-Like Receptor 4 - biosynthesis; Toll-Like Receptor 4 - genetics; Toll-like Receptors (TLR); Japan; Gene Regulation; Toll-like Receptors (TLR); MicroRNA; Innate Immunity; Periodontal Disease; Genetic Polymorphism; Lipopolysaccharide (LPS)

Background: Genetic variation of SNP rs11536889 in 3′-UTR of TLR4 is implicated in certain diseases, including periodontitis, gastric atrophy, and prostate cancer. Results: The G allele of rs11536889 inhibited translation, but not transcription, of TLR4. Conclusion: Genetic variation of rs11536889 r...