miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis

• Published in: Cell death & disease Vol. 8; no. 4; p. e2739
• Main Authors: Liu, Yankun, Zhang, Yingnan, Wu, Haidong, Li, Yufeng, Zhang, Yi, Liu, Min, Li, Xin, Tang, Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2017; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/2; 13/31; 38/77; 42/109; 631/337/384/331; 631/80/84/2176; 692/699/67/1504/1885; 692/699/67/322; Actins - genetics; Actins - metabolism; Anoikis; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Line, Tumor; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Immunology; Life Sciences; Male; Matrix Metalloproteinase 14 - genetics; Matrix Metalloproteinase 14 - metabolism; Metastasis; MicroRNAs; MicroRNAs - biosynthesis; MicroRNAs - genetics; Neoplasm Metastasis; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Original; original-article; RNA, Neoplasm - biosynthesis; RNA, Neoplasm - genetics

MicroRNAs (miRNAs) have a critical role in tumorigenesis and metastasis, which are major obstacles of cancer therapy. However, the role of miRNAs in colorectal cancer (CRC) metastasis remains poorly understood. Here, we found that miRNA-10a (miR-10a) was upregulated in primary CRC tissues and cell l...