Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

• Published in: Molecular therapy Vol. 26; no. 2; pp. 568 - 581
• Main Authors: Hsu, Ya-Ling, Hung, Jen-Yu, Chang, Wei-An, Jian, Shu-Fang, Lin, Yi-Shiuan, Pan, Yi-Chung, Wu, Cheng-Ying, Kuo, Po-Lin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.02.2018; Elsevier Limited; American Society of Gene & Cell Therapy
• Subjects: 3' Untranslated Regions; AKT protein; Angiogenesis; Cell adhesion & migration; Cell Line, Tumor; Cytokines; Cytokines - metabolism; Disease Progression; extracellular vesicle; Gene Expression Regulation, Neoplastic; Genotype & phenotype; Humans; Hypoxia; Hypoxia - genetics; Hypoxia - metabolism; Immunoglobulins; Immunotherapy; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Macrophage Activation - genetics; Macrophage Activation - immunology; Macrophages; Macrophages - metabolism; Medical prognosis; Medical research; Metastases; Metastasis; MicroRNAs; MicroRNAs - genetics; miR-103a; miRNA; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Original; Phosphatidylinositol 3-Kinases - metabolism; Polarization; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN protein; RNA Interference; RNA polymerase; Stat3 protein; STAT3 Transcription Factor - metabolism; Stroma; Tumor necrosis factor-TNF; Variance analysis; Vascular endothelial growth factor; United States > US; lung cancer; miR-103a; hypoxia; extracellular vesicle

Hypoxia, the most commonly observed characteristic in cancers, is implicated in the establishment of an immunosuppressive niche. Recent studies have indicated that extracellular vesicle (EV)-mediated cancer-stroma interactions are considered to play a critical role in the regulation of various cellu...