Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3′-kinase (PI3K) pathway is inhibited

• Published in: Oncogene Vol. 22; no. 30; pp. 4690 - 4701
• Main Authors: Molton, Sarah A, Todd, Daniel E, Cook, Simon J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.07.2003; Nature Publishing; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; Animals; Apoptosis; Bcl-2 protein; bcl-2-Associated X Protein; BIM protein; Biological and medical sciences; Blotting, Western; c-Jun protein; Carrier Proteins - metabolism; Cell activation; Cell Biology; Cell Cycle; Cell Death; Cell growth; Cell Line; Cell physiology; Cell Survival; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cellular stress response; Conditional mutant; Cricetinae; Cycloheximide; Down-Regulation; Enzyme Activation; Extracellular signal-regulated kinase; FasL protein; Fibroblasts; Fibroblasts - metabolism; Fundamental and applied biological sciences. Psychology; Gentian Violet; Human Genetics; I-kappa B Proteins - metabolism; Internal Medicine; JNK Mitogen-Activated Protein Kinases; JNK protein; Kinases; Mcl-1 protein; Medicine; Medicine & Public Health; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; Molecular and cellular biology; Mutation; NF-KappaB Inhibitor alpha; Oncology; original-paper; p38 Mitogen-Activated Protein Kinases; Pain perception; Phosphatidylinositol 3-Kinases - metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plasmids - metabolism; Protein Conformation; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction; Time Factors; Transcription factors; Transfection; Bcl-2; apoptosis; MEKK1; PI3K; JNK; PKB; Phosphoinositide; Regulation(control); Enzyme; Kinase; Transferases; Activation; P13K; Apoptosis
• ISSN: 0950-9232; 1476-5594
• DOI: 10.1038/sj.onc.1206692

c-Jun N-terminal kinase (JNK) is activated when cells are exposed to noxious stimuli. The role of JNK in apoptosis is subject to considerable debate; for example, JNK activation may promote or inhibit apoptosis depending on the cell type and stimulus involved. These conflicting results have arisen i...