Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

• Published in: eLife Vol. 10
• Main Authors: Ramos, M Ines Pascoal, Tian, Linjie, de Ruiter, Emma J, Song, Chang, Paucarmayta, Ana, Singh, Akashdip, Elshof, Eline, Vijver, Saskia V, Shaik, Jahangheer, Bosiacki, Jason, Cusumano, Zachary, Jensen, Christina, Willumsen, Nicholas, Karsdal, Morten A, Liu, Linda, Langermann, Sol, Willems, Stefan, Flies, Dallas, Meyaard, Linde
• Format: Journal Article
• Language: English
• Published: Cambridge eLife Science Publications, Ltd 14.06.2021; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animal models; Cancer; Cancer Biology; Cancer immunotherapy; Care and treatment; Cell growth; Collagen; Drug therapy; Esophageal cancer; Extracellular matrix; Fc receptors; Immunoglobulin G; Immunotherapy; LAIR1; Liver cancer; Lymphocytes T; Medical prognosis; Ovarian cancer; Proteins; Survival analysis; T cells; tumor; Tumors; Xenografts; Morocco

Collagens are a primary component of the extracellular matrix and are functional ligands for the inhibitory immune receptor leukocyte-associated immunoglobulin-like receptor (LAIR)-1. LAIR-2 is a secreted protein that can act as a decoy receptor by binding collagen with higher affinity than LAIR-1....