Normal Cellular Prion Protein Protects against Manganese-Induced Oxidative Stress and Apoptotic Cell Death

• Published in: Toxicological sciences Vol. 98; no. 2; pp. 495 - 509
• Main Authors: Choi, Christopher J., Anantharam, Vellareddy, Saetveit, Nathan J., Houk, Robert S., Kanthasamy, Arthi, Kanthasamy, Anumantha G.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.08.2007
• Subjects: Animals; Apoptosis; Caspase 3 - metabolism; Caspase 9 - metabolism; caspases; Cell Line; DNA Fragmentation; Glutathione - metabolism; manganese; Manganese - toxicity; metals; Mice; Mice, Knockout; Neurons; neurotoxicity; Oxidative Stress; prion disease; PrPC Proteins - deficiency; PrPC Proteins - genetics; PrPC Proteins - metabolism; Reactive Oxygen Species - metabolism; ROS; Superoxide Dismutase - metabolism; metals; neurotoxicity; prion disease; manganese; caspases; ROS

The normal prion protein is abundantly expressed in the central nervous system, but its biological function remains unclear. The prion protein has octapeptide repeat regions that bind to several divalent metals, suggesting that the prion proteins may alter the toxic effect of environmental neurotoxi...