The Phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii Reveal Unusual Adaptations Within and Beyond the Parasites' Boundaries

• Published in: Cell host & microbe Vol. 10; no. 4; pp. 410 - 419
• Main Authors: Treeck, Moritz, Sanders, John L., Elias, Joshua E., Boothroyd, John C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.10.2011
• Subjects: Adaptation, Biological; Chromatography, Liquid; data collection; Gene Expression Regulation; genome; host-pathogen relationships; liquid chromatography; Mass Spectrometry; parasites; peptides; Phosphoproteins - analysis; Phosphorylation; Plasmodium falciparum; Plasmodium falciparum - chemistry; Plasmodium falciparum - genetics; Plasmodium falciparum - physiology; protein phosphorylation; Protein Processing, Post-Translational; Proteome - analysis; Signal Transduction; tachyzoites; tandem mass spectrometry; Toxoplasma - chemistry; Toxoplasma - genetics; Toxoplasma - physiology; Toxoplasma gondii

Plasmodium falciparum and Toxoplasma gondii are obligate intracellular apicomplexan parasites that rapidly invade and extensively modify host cells. Protein phosphorylation is one mechanism by which these parasites can control such processes. Here we present a phosphoproteome analysis of peptides en...